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68th Annual Meeting of the German Society of Neuropathology and Neuroanatomy (DGNN) - Meeting Abstracts, September 12–14, 2024

Free Neuropathology
Dear colleagues, It is my pleasure and honor to host the 68th Annual Meeting of the German Society of Neuropathology and Neuroanatomy (DGNN) in Regensburg.
German Society of Neuropathology and Neuroanatomy (DGNN)
doaj   +1 more source

Spinocerebellar Ataxia Type 2 [PDF]

, 2012
1. Introduction: The autosomal dominant cerebellar ataxias (ADCA) are a clinically, pathologically and genetically heterogeneous group of neurodegenerative disorders caused by degeneration of cerebellum and its afferent and efferent connections.
Auburger, Georg, Freund, Hans-Joachim, Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis   +3 more
core   +1 more source

Astrocyte Interactions With Ti3C2Tx MXene Flakes: Insights Into Viability, Morphology, and Functionality

Advanced Materials Interfaces, EarlyView.
This study presents the first systematic evaluation of interactions between astrocytes and Ti3C2TX MXene flakes, a 2D nanomaterial with emerging neuroelectronic applications. Using a multimodal approach, including viability assays, morphometric analysis, and calcium imaging, this work demonstrates high biocompatibility and preserved function in ...
Dimitris Boufidis, Elizabeth N. Krizman, Cybelle M. Smith, Yihan Xie, Raghav Garg, John C. O'Donnell, Flavia Vitale, D. Kacy Cullen   +7 more
wiley   +1 more source

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]

, 2008
Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Czirr, Eva, Esselmann, Hermann, Leuchtenberger, Stefanie, Lichtenthaler, Stefan F., Maler, Juan, Ness, Julia, Pietrzik, Claus U., Weggen, Sascha, Wiltfang, Jens   +8 more
core   +1 more source

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, EarlyView.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum

Frontiers in Neurology, 2023
IntroductionThe measurement of neurofilament light chain (NfL) in blood is a promising biomarker of neurological injury and disease. We investigated the genetic factors that underlie serum NfL levels (sNfL) of individuals without neurological conditions ...
Marisol Herrera-Rivero, Edith Hofer, Edith Hofer, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Reinhold Schmidt, Michael Khalil, Heinz Wiendl, Monika Stoll, Monika Stoll, Klaus Berger   +12 more
doaj   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Angewandte Chemie, EarlyView.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij, Vito Pol, Jin Gan, Bjorn R. van Doodewaerd, Aysegul Sapmaz, Marta Campos Alonso, Günter Fritz, Klaus‐Peter Knobeloch, Paul P. Geurink   +8 more
wiley   +2 more sources

A Case Report of Acute Disseminated Encephalomyelitis in a Pregnant Woman After COVID-19 Infection

Türk Nöroloji Dergisi, 2021
A 32-year-old multiparous woman at 29 weeks of gestation developed dizziness, fainting, meaningless and difficult speech, stiffness in the extremities, and movement limitation following the non-severe coronavirus disease-2019 (COVID-19) infection ...
Rukiye Kızılırmak, Miraç Özalp, Mehmet Armağan Osmanağaoğlu, Cavit Boz   +3 more
doaj   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source