Results 1 to 10 of about 423,580 (268)

Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy

Frontiers in Neuroscience, 2019
The incidence of diabetes mellitus is approaching global epidemic proportions and should be considered a major health-care problem of modern societies in the twenty-first century.
Mette Richner, Nelson Ferreira, Anete Dudele, Anete Dudele, Troels S. Jensen, Troels S. Jensen, Christian B. Vaegter, Christian B. Vaegter, Nádia P. Gonçalves, Nádia P. Gonçalves   +9 more
doaj   +2 more sources

The PINK1 Activator Niclosamide Mitigates Mitochondrial Dysfunction and Thermal Hypersensitivity in a Paclitaxel-Induced Drosophila Model of Peripheral Neuropathy

Biomedicines, 2022
Paclitaxel is a widely used anticancer drug that induces dose-limiting peripheral neuropathy. Mitochondrial dysfunction has been implicated in paclitaxel-induced neuronal damage and in the onset of peripheral neuropathy. We have previously shown that the
Hye-Ji Jang, Young-Yeon Kim, Kang-Min Lee, Jung-Eun Shin, Jeanho Yun   +4 more
doaj   +1 more source

Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID

Neurology: Neuroimmunology & Neuroinflammation, 2022
Background and Objectives Recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appears exponential, leaving a tail of patients reporting various long COVID symptoms including unexplained fatigue/exertional intolerance and ...
A. Oaklander, Alexander J Mills, M. Kelley, Lisa S Toran, Bryan R. Smith, M. Dalakas, A. Nath   +6 more
semanticscholar   +1 more source

The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?

Pharmaceuticals, 2021
Preclinical evidence, accumulated over the past decade, indicates that the angiotensin II type 2 receptor (AT2R) stimulation exerts significant neuroprotective effects in various animal models of neuronal injury, notably in the central nervous system ...
Aurore Danigo, Amandine Rovini, Flavien Bessaguet, Hichem Bouchenaki, Amandine Bernard, Franck Sturtz, Sylvie Bourthoumieu, Alexis Desmoulière, Laurent Magy, Claire Demiot   +9 more
doaj   +1 more source

Falls and fractures associated with type 2 diabetic polyneuropathy: A cross‐sectional nationwide questionnaire study

Journal of Diabetes Investigation, 2021
Aims/Introduction To examine the prevalence of falls and fractures, and the association with symptoms of diabetic polyneuropathy (DPN) in patients with recently diagnosed type 2 diabetes.
Karolina Snopek Khan, Diana Hedevang Christensen, Sia Kromann Nicolaisen, Sandra Sif Gylfadottir, Troels Staehelin Jensen, Jens Steen Nielsen, Reimar Wernich Thomsen, Henning Andersen   +7 more
doaj   +1 more source

Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice

Frontiers in Pharmacology, 2021
Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia.
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Laurent Magy, Claire Demiot   +10 more
doaj   +1 more source

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update.

Journal of Clinical Oncology, 2020
PURPOSE To update the ASCO guideline on the recommended prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivors.
C. Loprinzi, C. Lacchetti, J. Bleeker, G. Cavaletti, C. Chauhan, D. Hertz, M. Kelley, A. Lavino, M. Lustberg, J. Paice, B. Schneider, Ellen M. Lavoie Smith, M. Smith, Thomas J. Smith, N. Wagner-Johnston, D. Hershman   +15 more
semanticscholar   +1 more source

The Flavonoid Hesperidin Methyl Chalcone Targets Cytokines and Oxidative Stress to Reduce Diclofenac-Induced Acute Renal Injury: Contribution of the Nrf2 Redox-Sensitive Pathway

Antioxidants, 2022
Hesperidin is derived from citrus fruits among other plants. Hesperidin was methylated to increase its solubility, generating hesperidin methyl chalcone (HMC), an emerging flavonoid that possess anti-inflammatory and antioxidant properties.
Allan J. C. Bussmann, Tiago H. Zaninelli, Telma Saraiva-Santos, Victor Fattori, Carla F. S. Guazelli, Mariana M. Bertozzi, Ketlem C. Andrade, Camila R. Ferraz, Doumit Camilios-Neto, Antônio M. B. Casella, Rubia Casagrande, Sergio M. Borghi, Waldiceu A. Verri   +12 more
doaj   +1 more source

Resolvin D5 (RvD5) Reduces Renal Damage Caused by LPS Endotoxemia in Female Mice

Molecules, 2022
In self-revolving gram-negative Escherichia coli infection, Resolvin D5 (RvD5) was found to enhance bacteria phagocytosis and reduce the production of inflammatory mediators, contributing to the resolution of infection. LPS (lipopolysaccharide) is a gram-
Renato D. R. Cardoso, Sandmary D. Chambo, Tiago H. Zaninelli, Beatriz H. S. Bianchini, Matheus Deroco Veloso da Silva, Mariana M. Bertozzi, Telma Saraiva-Santos, Anelise Franciosi, Geovana Martelossi-Cebinelli, Pamela E. Garcia-Miguel, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri   +12 more
doaj   +1 more source

Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions

Scientific Reports, 2021
Pyruvate functions as a key molecule in energy production and as an antioxidant. The efficacy of pyruvate supplementation in diabetic retinopathy and nephropathy has been shown in animal models; however, its significance in the functional maintenance of ...
Hideji Yako, Naoko Niimi, Ayako Kato, Shizuka Takaku, Yasuaki Tatsumi, Yasumasa Nishito, Koichi Kato, Kazunori Sango   +7 more
doaj   +1 more source