A Stochastic Multiscale Model that Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases [PDF]
, 2015 The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two axonal cytoskeletal polymers microtubules and neurofilaments align longitudinally in axons and are interspersed in axonal cross-sections.
arxiv +1 more source
Updates in diabetic peripheral neuropathy
F1000Research, 2016 Diabetes has become one of the largest global health-care problems of the 21 st century. According to the Centers for Disease Control and Prevention, the population prevalence of diabetes in the US is approaching 10% and is increasing by 5% each year ...
Kelsey Juster-Switlyk +4 more
semanticscholar +1 more source
Alcohol-related peripheral neuropathy: a systematic review and meta-analysis
Journal of Neurology, 2018 The primary aim of this systematic review was to establish the prevalence, character, and risk factors of peripheral neuropathy amongst chronic alcohol abusers and to identify the most appropriate management strategies.
T. Julian +3 more
semanticscholar +1 more source
Neuropathy and Diabetic Foot Syndrome
International Journal of Molecular Sciences, 2016 Diabetic foot ulceration is a serious complication of diabetes mellitus worldwide and the most common cause of hospitalization in diabetic patients.
Maren Volmer-Thole, R. Lobmann
semanticscholar +1 more source
Evaluation of an AI system for the automated detection of glaucoma from stereoscopic optic disc photographs: the European Optic Disc Assessment Study [PDF]
arXiv, 2019 Objectives: To evaluate the performance of a deep learning based Artificial Intelligence (AI) software for detection of glaucoma from stereoscopic optic disc photographs, and to compare this performance to the performance of a large cohort of ophthalmologists and optometrists. Methods: A retrospective study evaluating the diagnostic performance of an
arxiv
Iron role paradox in nerve degeneration and regeneration [PDF]
Bolandghamat, S., & Behnam-Rassouli, M. (2024). Iron role paradox
in nerve degeneration and regeneration. Physiological Reports, 12, e15908Iron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de-differentiation. On the other hand, intracellular iron levels remain elevated during nerve regeneration and gradually decrease.
arxiv +1 more source
Model-based clustering for identifying disease-associated SNPs in case-control genome-wide association studies [PDF]
, 2018 Genome-wide association studies (GWASs) aim to detect genetic risk factors for complex human diseases by identifying disease-associated single-nucleotide polymorphisms (SNPs). The traditional SNP-wise approach along with multiple testing adjustment is over-conservative and lack of power in many GWASs.
arxiv +1 more source
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Journal of Alternative and Complementary Medicine, 2017 OBJECTIVES Neuropathy and its associated pain pose great therapeutic challenges. While there has been a recent surge in acupuncture use and research, little remains known about its effects on nerve function.
Alexandra Dimitrova +2 more
semanticscholar +1 more source
PharmaceuticalsBackground/Objectives: Fructose-1,6-bisphosphate (FBP) is an intermediate product of the glycolytic pathway with analgesic effect in acute inflammatory pain model via the production of adenosine.
Amanda Martins Dionisio +9 more
doaj +1 more source
Hypoxia-inducible factor 1a protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species [PDF]
arXiv, 2018 Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain large unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of ROS have gained attention as possible mechanisms of organ damage in diabetes ...
arxiv