Results 61 to 70 of about 342,736 (199)

A Narrative Review of the Dorsal Root Ganglia and Spinal Cord Mechanisms of Action of Neuromodulation Therapies in Neuropathic Pain

open access: yesBrain Sciences
Neuropathic pain arises from injuries to the nervous system in diseases such as diabetes, infections, toxicity, and traumas. The underlying mechanism of neuropathic pain involves peripheral and central pathological modifications.
Matheus Deroco Veloso da Silva   +6 more
doaj   +1 more source

Neuropathy [PDF]

open access: yesCanadian Journal of Diabetes, 2013
Vera, Bril, Bruce, Perkins, Cory, Toth
openaire   +2 more sources

Clinical Features and Genetic Analysis of Drug-resistant Epilepsy in Children [PDF]

open access: yesZhongguo quanke yixue
Background At present, the proportion of DRUG-RESISTANT epilepsy (DRE) in children is still maintained at about 30%, and it is often combined with mental retardation, affecting the quality of life, so the diagnosis and treatment of DRE is still a major ...
ZUO Ranran, SUN Suzhen
doaj   +1 more source

Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy

open access: yesFrontiers in Neuroscience, 2019
The incidence of diabetes mellitus is approaching global epidemic proportions and should be considered a major health-care problem of modern societies in the twenty-first century.
Mette Richner   +9 more
doaj   +1 more source

C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration

open access: yesBrain Sciences, 2019
Tobacco smoking is the major cause of disability and death in the United States and around the world. In addition, tobacco dependence and addiction express themselves as complex behaviors involving an interplay of genetics, environment, and psychological
Lois S. Akinola   +6 more
doaj   +1 more source

A multicenter study on the prevalence of diabetic neuropathy in Italy. Italian Diabetic Neuropathy Committee.

open access: yes, 1997
The prevalence of neuropathy, a common complication of diabetes, was determined in diabetic patients recruited from 109 outpatient diabetes clinics in Italy.Neuropathy was diagnosed using the Diabetic Neuropathy Index (DNI), a standardized examination ...
P. Negrin   +11 more
core  

p62/sequestosome-1 as a severity-reflecting plasma biomarker in Charcot–Marie–Tooth disease type 1A

open access: yesScientific Reports
Autophagy is a self-degradation system for recycling to maintain homeostasis. p62/sequestosome-1 (p62) is an autophagy receptor that accumulates in neuroglia in neurodegenerative diseases.
Byeol-A Yoon   +10 more
doaj   +1 more source

Superoxide Anion Generation, Its Pathological Cellular and Molecular Roles and Pharmacological Targeting in Inflammatory Pain: Lessons from the Potassium Superoxide Model

open access: yesFuture Pharmacology
Reactive oxygen species (ROS) are formed by the incomplete reduction of oxygen and play a crucial role in both physiological function and pathological process, being controlled by enzymatic and non-enzymatic antioxidant systems.
Beatriz Hoffmann Sales Bianchini   +5 more
doaj   +1 more source

Natural agents mediated autophagic signal networks in cancer

open access: yesCancer Cell International, 2017
Recent studies suggested that natural compounds are important in finding targets for cancer treatments. Autophagy (“self-eating”) plays important roles in multiple diseases and acts as a tumor suppressor in cancer.
Eun Jung Sohn, Hwan Tae Park
doaj   +1 more source

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

open access: yes, 2019
HSPB1 (heat shock protein family B [small] member 1) is a ubiquitously expressed molecular chaperone. Most mutations in HSPB1 cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy.
Mansour Haidar (6255134)   +7 more
core   +1 more source

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