Results 81 to 90 of about 423,580 (268)

Comorbidities and Risk of Chemotherapy-Induced Peripheral Neuropathy Among Participants 65 Years or Older in Southwest Oncology Group Clinical Trials.

Journal of Clinical Oncology, 2016
BACKGROUND Neuropathy is a debilitating toxicity associated with various chemotherapy agents. We evaluated the association between common comorbid conditions and the development of peripheral neuropathy in patients treated with taxane-based chemotherapy.
D. Hershman, Cathee Till, J. Wright, D. Awad, S. Ramsey, W. Barlow, L. Minasian, J. Unger   +7 more
semanticscholar   +1 more source

C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration

Brain Sciences, 2019
Tobacco smoking is the major cause of disability and death in the United States and around the world. In addition, tobacco dependence and addiction express themselves as complex behaviors involving an interplay of genetics, environment, and psychological
Lois S. Akinola, Bryan Mckiver, Wisam Toma, Andy Z. X. Zhu, Rachel F. Tyndale, Vivek Kumar, M. Imad Damaj   +6 more
doaj   +1 more source

Sural Nerve Perfusion in Mice

Frontiers in Neuroscience, 2020
Peripheral nerve function is metabolically demanding and nerve energy failure has been implicated in the onset and development of diabetic peripheral neuropathy and neuropathic pain conditions.
Anete Dudele, Anete Dudele, Peter Mondrup Rasmussen, Leif Østergaard, Leif Østergaard, Leif Østergaard   +5 more
doaj   +1 more source

The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review

BMC Cancer, 2018
BackgroundAlthough acute oxaliplatin-induced neuropathy (OXIPN) is frequently regarded to be transient, recent studies have reported prolongation of infusion times, dose reduction and treatment cessation following the first dose of oxaliplatin in quarter
E. G. Gebremedhn, P. Shortland, D. Mahns
semanticscholar   +1 more source

Maresin-2 inhibits inflammatory and neuropathic trigeminal pain and reduces neuronal activation in the trigeminal ganglion

Current Research in Neurobiology, 2023
Pain is a common symptom associated with disorders involving the orofacial structures. Most acute orofacial painful conditions are easily recognized, but the pharmacological treatment may be limited by the adverse events of current available drugs and/or
Raphael Vieira Lopes, Darciane Favero Baggio, Camila Rodrigues Ferraz, Mariana Marques Bertozzi, Telma Saraiva-Santos, Waldiceu Aparecido Verri Junior, Juliana Geremias Chichorro   +6 more
doaj  

Clinical Features and Genetic Analysis of Drug-resistant Epilepsy in Children [PDF]

Zhongguo quanke yixue
Background At present, the proportion of DRUG-RESISTANT epilepsy (DRE) in children is still maintained at about 30%, and it is often combined with mental retardation, affecting the quality of life, so the diagnosis and treatment of DRE is still a major ...
ZUO Ranran, SUN Suzhen
doaj   +1 more source

Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy [PDF]

arXiv, 2018
Diabetic-induced peripheral neuropathy (DPN) is a diabetic late complication. The molecular mechanisms underlying the pathophysiology of nerve damage & sensory loss remain largely unclear. Recently, alterations in metabolic flux have gained attention a basis for organ damage in diabetes; however, peripheral sensory neurons have not been adequately ...
arxiv  

Role of inflammatory biomarkers in diabetic peripheral neuropathy

Journal of Diabetes Investigation, 2018
Inflammatory pathway from hyperglycemia to diabetic peripheral neuropathy is very important in diagnosis and management. Inflammatory cytokine can be used for prediction and progression of diabetic peripheral neuropathy.
H. Jin, T. Park
semanticscholar   +1 more source

A Narrative Review of the Dorsal Root Ganglia and Spinal Cord Mechanisms of Action of Neuromodulation Therapies in Neuropathic Pain

Brain Sciences
Neuropathic pain arises from injuries to the nervous system in diseases such as diabetes, infections, toxicity, and traumas. The underlying mechanism of neuropathic pain involves peripheral and central pathological modifications.
Matheus Deroco Veloso da Silva, Geovana Martelossi-Cebinelli, Kelly Megumi Yaekashi, Thacyana T. Carvalho, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri   +6 more
doaj   +1 more source

Natural agents mediated autophagic signal networks in cancer

Cancer Cell International, 2017
Recent studies suggested that natural compounds are important in finding targets for cancer treatments. Autophagy (“self-eating”) plays important roles in multiple diseases and acts as a tumor suppressor in cancer.
Eun Jung Sohn, Hwan Tae Park
doaj   +1 more source