Results 11 to 20 of about 3,171 (209)

Neuropatologia [PDF]

Journal of Neuropathology and Experimental Neurology, 1983
exaly   +2 more sources

Towards a methodological uniformization of environmental risk studies in Parkinson’s disease [PDF]

npj Parkinson's Disease
Bruno Lopes Santos-Lobato
doaj   +2 more sources

Prospective Longitudinal Cohort of Argentinean Patients with Progressive Supranuclear Palsy: A Platform for Epidemiological and Translational Research [PDF]

Alzheimers Dement
Abstract Background Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are two neurodegenerative disorders that manifest disabling postural instability, parkinsonism, cognitive impairment and falls with brain neurofibrillary tangle lesions containing 4‐repeat tau protein. The prevalence is 6/100,000 inhabitants but estimated only from
Couto B, Pinto M, Avale M, Falzone T, Gershanik O, Chade A, Mizraji G, Gonzalez‐Toledo M, Peralta M, Gomez‐Arevalo G, Mezmezian M, Marras C, Sevlever G.   +12 more
europepmc   +2 more sources

Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Most genetic studies for Alzheimer's disease (AD) have been focused on late‐onset AD (LOAD). There are no large genetic studies on early‐onset AD (EOAD). METHODS We performed a multi‐ancestry (non‐Hispanic European, African, and East Asian) genome‐wide association study (GWAS) including a total of 7,349 cases and 17,887 control ...
Bradley J, Pottier C, da Fonseca EL, Kurup JT, Western D, Wang C, Neupane A, Ray NR, Jean-Francois M, Ali M, Timsina J, Bergmann K, Budde J, Martin ER, Pericak-Vance MA, Cuccaro M, Naj AC, Kunkle BW, Alzheimer's Disease Genetics Consortium (ADGC), Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight‐ADRC), Schellenberg GD, Fernandez V, Haines J, Morris JC, Holtzman DM, Perrin RJ, Reitz C, Beecham GW, Cruchaga C.   +28 more
europepmc   +2 more sources

Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria

Veterinary and Comparative Oncology, Volume 21, Issue 4, Page 685-699, December 2023., 2023
Abstract Canine meningiomas are currently graded using the human grading system. Recently published guidelines have adapted the human grading system for use in dogs. The goal of this study was to validate the new guidelines for canine meningiomas. To evaluate the inter‐observer agreement, 5 veterinary surgical pathologists graded 158 canine meningiomas
Sara Belluco, Giuseppe Marano, Thibaut Lurier, Giancarlo Avallone, Chiara Brachelente, Stefano Di Palma, Roberta Rasotto, Kerstin Baiker, Andreas Beineke, Anna Oevermann, Frauke Seehusen, Fabiano José Ferreira de Sant'Ana, Patrizia Boracchi, Martí Pumarola, Maria Teresa Mandara   +14 more
wiley   +1 more source

Monomeric C‐reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction

Brain Pathology, Volume 33, Issue 6, November 2023., 2023
The extraordinary complexity, and pathological biological activity, of monomeric C‐reactive protein within the brain parenchyma. Abstract Circulating C‐reactive protein (pCRP) concentrations rise dramatically during both acute (e.g., following stroke) or chronic infection and disease (e.g., autoimmune conditions such as lupus), providing complement ...
Ylenia Pastorello, Roxana O. Carare, Claudia Banescu, Lawrence Potempa, Mario Di Napoli, Mark Slevin   +5 more
wiley   +1 more source

Abstracts from the Conference Neuropatologia Neuroscience

Folia Neuropathologica, 2021
doaj   +2 more sources

Sex‐ and APOE‐specific genetic risk factors for late‐onset Alzheimer's disease: Evidence from gene–gene interaction of longevity‐related loci

Aging Cell, Volume 22, Issue 9, September 2023., 2023
Genetic studies over the last few years, have changed the perception of late‐onset Alzheimer's disease (LOAD), highlighting its polygenic nature with multiple susceptibility genetic loci. We applied a multidimensional reduction approach to detect gene–gene interactions affecting LOAD by testing variants harbored by genes previously investigated in ...
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni   +9 more
wiley   +1 more source

Modulation of the autophagy‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke

Journal of Neurochemistry, Volume 166, Issue 1, Page 87-106, July 2023., 2023
We report for the first time that the protective effect of β‐hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D‐BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D‐BHB notably reduced the activation
Teresa Montiel, Juan Carlos Gómora‐García, Cristian Gerónimo‐Olvera, Yessica Heras‐Romero, Berenice N. Bernal‐Vicente, Xochitl Pérez‐Martínez, Luis B. Tovar‐y‐Romo, Lourdes Massieu   +7 more
wiley   +1 more source

Blockade of Ca_V3 calcium channels and induction of G₀/G₁ cell cycle arrest in colon cancer cells by gossypol. [PDF]

Br J Pharmacol
Abstract Background and Purpose Gastrointestinal tumours overexpress voltage‐gated calcium (CaV3) channels (CaV3.1, 3.2 and 3.3). CaV3 channels regulate cell growth and apoptosis colorectal cancer. Gossypol, a polyphenolic aldehyde found in the cotton plant, has anti‐tumour properties and inhibits CaV3 currents.
Lopez-Charcas O, Benouna O, Lemoine R, Rosendo-Pineda MJ, Anguheven-Ledezma TG, Sandoval-Vazquez L, Gallegos-Gomez ML, Robles-Martinez L, Herrera-Carrillo Z, Ramírez-Aragón M, Alfaro A, Chadet S, Ferro F, Besson P, Jiang LH, Velu SE, Guerrero-Hernandez A, Roger S, Gomora JC.   +18 more
europepmc   +2 more sources