Results 11 to 20 of about 1,464 (162)

Impact of a Public Health Policy on Accessibility to Levodopa for People with Parkinson's Disease in Brazil. [PDF]

Mov Disord Clin Pract
Movement Disorders Clinical Practice, Volume 13, Issue 5, Page 1356-1358, May 2026.
Duarte JDS, Pedrosa LRR, Gomes RSG, Santos-Lobato BL.   +3 more
europepmc   +2 more sources

Revisiting the Association of Pesticide Exposure and Parkinson's Disease: Systematic Review and Meta-Analysis. [PDF]

Environ Toxicol
ABSTRACT The association between pesticide exposure and Parkinson's disease (PD) is substantial, but heterogeneity in methodology and lack of categorization according to the type of exposure and pesticide classes in previous meta‐analyses impair the interpretation of data. This study aims to update evidence of the association between pesticide exposure
da Silva PHP, Abreu JS, Gomes RSG, Oliveira HKA, Schuh AFS, Mata IF, Santos-Lobato BL.   +6 more
europepmc   +2 more sources

Prospective Longitudinal Cohort of Argentinean Patients with Progressive Supranuclear Palsy: A Platform for Epidemiological and Translational Research [PDF]

Alzheimers Dement
Abstract Background Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are two neurodegenerative disorders that manifest disabling postural instability, parkinsonism, cognitive impairment and falls with brain neurofibrillary tangle lesions containing 4‐repeat tau protein. The prevalence is 6/100,000 inhabitants but estimated only from
Couto B, Pinto M, Avale M, Falzone T, Gershanik O, Chade A, Mizraji G, Gonzalez‐Toledo M, Peralta M, Gomez‐Arevalo G, Mezmezian M, Marras C, Sevlever G.   +12 more
europepmc   +2 more sources

Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria

Veterinary and Comparative Oncology, Volume 21, Issue 4, Page 685-699, December 2023., 2023
Abstract Canine meningiomas are currently graded using the human grading system. Recently published guidelines have adapted the human grading system for use in dogs. The goal of this study was to validate the new guidelines for canine meningiomas. To evaluate the inter‐observer agreement, 5 veterinary surgical pathologists graded 158 canine meningiomas
Sara Belluco, Giuseppe Marano, Thibaut Lurier, Giancarlo Avallone, Chiara Brachelente, Stefano Di Palma, Roberta Rasotto, Kerstin Baiker, Andreas Beineke, Anna Oevermann, Frauke Seehusen, Fabiano José Ferreira de Sant'Ana, Patrizia Boracchi, Martí Pumarola, Maria Teresa Mandara   +14 more
wiley   +1 more source

Monomeric C‐reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction

Brain Pathology, Volume 33, Issue 6, November 2023., 2023
The extraordinary complexity, and pathological biological activity, of monomeric C‐reactive protein within the brain parenchyma. Abstract Circulating C‐reactive protein (pCRP) concentrations rise dramatically during both acute (e.g., following stroke) or chronic infection and disease (e.g., autoimmune conditions such as lupus), providing complement ...
Ylenia Pastorello, Roxana O. Carare, Claudia Banescu, Lawrence Potempa, Mario Di Napoli, Mark Slevin   +5 more
wiley   +1 more source

Sex‐ and APOE‐specific genetic risk factors for late‐onset Alzheimer's disease: Evidence from gene–gene interaction of longevity‐related loci

Aging Cell, Volume 22, Issue 9, September 2023., 2023
Genetic studies over the last few years, have changed the perception of late‐onset Alzheimer's disease (LOAD), highlighting its polygenic nature with multiple susceptibility genetic loci. We applied a multidimensional reduction approach to detect gene–gene interactions affecting LOAD by testing variants harbored by genes previously investigated in ...
Serena Dato, Francesco De Rango, Paolina Crocco, Stefano Pallotti, Michael E. Belloy, Yann Le Guen, Michael D. Greicius, Giuseppe Passarino, Giuseppina Rose, Valerio Napolioni   +9 more
wiley   +1 more source

Modulation of the autophagy‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke

Journal of Neurochemistry, Volume 166, Issue 1, Page 87-106, July 2023., 2023
We report for the first time that the protective effect of β‐hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D‐BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D‐BHB notably reduced the activation
Teresa Montiel, Juan Carlos Gómora‐García, Cristian Gerónimo‐Olvera, Yessica Heras‐Romero, Berenice N. Bernal‐Vicente, Xochitl Pérez‐Martínez, Luis B. Tovar‐y‐Romo, Lourdes Massieu   +7 more
wiley   +1 more source

Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel

The Journal of Physiology, Volume 601, Issue 9, Page 1655-1673, 1 May 2023., 2023
Abstract figure legend TRPV4 is differentially activated by distinct ligands. Lysophosphatidic acid 18:1 (LPA18:1) activates TRPV4 with a larger conductance as compared to lysophosphatidylcholine 18:1 (LPC18:1). These different modes of activation can lead to differences in cell excitability. Abstract The Transient Receptor Potential Vanilloid 4 (TRPV4)
Miguel Benítez‐Angeles, Ana E. López Romero, Itzel Llorente, Ileana Hernández‐Araiza, Ariela Vergara‐Jaque, Fernando H. Real, Óscar Eduardo Gutiérrez Castañeda, Marcelino Arciniega, Luis E. Morales‐Buenrostro, Francisco Torres‐Quiroz, Refugio García‐Villegas, Luis B. Tovar‐y‐Romo, Wolfgang B. Liedtke, León D. Islas, Tamara Rosenbaum   +14 more
wiley   +1 more source

Gill histology and ultrastructure in Aplysia depilans (Mollusca, Euopisthobranchia)

Journal of Morphology, Volume 284, Issue 3, March 2023., 2023
This study provides new information on the gill of euopisthobranch gastropods a subject still underexplored. In addition to the respiratory function, the gill epithelium is engaged in endocytosis and intracellular digestion, and the ultrastructural analysis also suggests a role in ion regulation.
Alexandre Lobo‐da‐Cunha, Ângela Alves, Aurora Rodrigues   +2 more
wiley   +1 more source

Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Most genetic studies for Alzheimer's disease (AD) have been focused on late‐onset AD (LOAD). There are no large genetic studies on early‐onset AD (EOAD). METHODS We performed a multi‐ancestry (non‐Hispanic European, African, and East Asian) genome‐wide association study (GWAS) including a total of 7,349 cases and 17,887 control ...
Bradley J, Pottier C, da Fonseca EL, Kurup JT, Western D, Wang C, Neupane A, Ray NR, Jean-Francois M, Ali M, Timsina J, Bergmann K, Budde J, Martin ER, Pericak-Vance MA, Cuccaro M, Naj AC, Kunkle BW, Alzheimer's Disease Genetics Consortium (ADGC), Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight‐ADRC), Schellenberg GD, Fernandez V, Haines J, Morris JC, Holtzman DM, Perrin RJ, Reitz C, Beecham GW, Cruchaga C.   +28 more
europepmc   +2 more sources