Results 21 to 30 of about 3,171 (209)
Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel
The Journal of Physiology, Volume 601, Issue 9, Page 1655-1673, 1 May 2023., 2023 Abstract figure legend TRPV4 is differentially activated by distinct ligands. Lysophosphatidic acid 18:1 (LPA18:1) activates TRPV4 with a larger conductance as compared to lysophosphatidylcholine 18:1 (LPC18:1). These different modes of activation can lead to differences in cell excitability. Abstract The Transient Receptor Potential Vanilloid 4 (TRPV4)
Miguel Benítez‐Angeles +14 more
wiley +1 more source
Gill histology and ultrastructure in Aplysia depilans (Mollusca, Euopisthobranchia)
Journal of Morphology, Volume 284, Issue 3, March 2023., 2023 This study provides new information on the gill of euopisthobranch gastropods a subject still underexplored. In addition to the respiratory function, the gill epithelium is engaged in endocytosis and intracellular digestion, and the ultrastructural analysis also suggests a role in ion regulation.
Alexandre Lobo‐da‐Cunha +2 more
wiley +1 more source
Alzheimer's &Dementia, Volume 18, Issue 11, Page 2042-2054, November 2022., 2022 Abstract Introduction The apolipoprotein E (APOE) ɛ2 allele reduces risk against Alzheimer's disease (AD) but mechanisms underlying this effect are largely unknown. Methods We conducted a genome‐wide association study for AD among 2096 ɛ2 carriers. The potential role of the top‐ranked gene and complement 4 (C4) proteins, which were previously linked to
Gyungah R. Jun +20 more
wiley +1 more source
Information theory approaches to improve glioma diagnostic workflows in surgical neuropathology
Brain Pathology, Volume 32, Issue 5, September 2022., 2022 Different clustering patterns with clinical, histologic, immunohistochemical, and molecular information on the brain cancer population simulation and information gain in the glioma simulation model for clinical decision‐making. Dimensionality reduction by principal component analysis is shown in A1–A4, and by t‐stochastic neighbor embedding in B1–B4 ...
Lokman Cevik +25 more
wiley +1 more source
Expression of Caspases and Their Substrates in the Rat Model of Focal Cerebral Ischemia
Neurobiology of Disease, 2000 Experimental evidence suggests that the massive release of glutamate during experimental brain ischemia both directly and indirectly regulates downstream mechanisms of cell suicide.
Jerzy Krupinski +3 more
doaj +1 more source
Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B. [PDF]
Alzheimers DementAbstract INTRODUCTION Transactive response DNA binding protein 43 kDa (TDP‐43) proteinopathy has been linked to cognitive decline and often co‐occurs with hippocampal sclerosis (HS). To identify genetic markers of TDP‐43 proteinopathy and HS, we performed genome‐wide association studies (GWASs) of HS and TDP‐43 inclusions.
Godrich D +28 more
europepmc +2 more sources
Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA [PDF]
, 2012 The current classification of human sporadic prion diseases recognizes six major phenotypic subtypes with distinctive clinicopathological features, which largely correlate at the molecular level with the genotype at the polymorphic codon 129 (methionine,
Cohen, Mark L +17 more
core +1 more source
Movement Disorders, Volume 37, Issue 8, Page 1593-1604, August 2022., 2022 Abstract Background Human genetics research lacks diversity; over 80% of genome‐wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation of personalized medicine.
Artur Francisco Schumacher‐Schuh +181 more
wiley +1 more source
Abnormal α-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease
Neurobiology of Disease, 2004 The present study examines α-synuclein interactions with rab3a and rabphilin by antibody arrays, immunoprecipitation and pull-down methods in the entorhinal cortex of control cases and in diffuse Lewy body disease (LBD) cases.
E Dalfó +4 more
doaj +1 more source