Results 101 to 110 of about 88,878 (295)

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu   +7 more
wiley   +1 more source

Accumulation of GSK‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission

open access: yesAging Cell, EarlyView.
Overexpression of GSK‐3β in DG GABAergic neurons impairs neurogenesis by reducing GABA release, which can be reversed by enhancing GABAergic transmission. ABSTRACT The activation of glycogen synthase kinase 3β (GSK‐3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD ...
Fei Liu   +11 more
wiley   +1 more source

In silico analysis of crustacean hyperglycemic hormone family G protein-coupled receptor candidates

open access: yesFrontiers in Endocrinology
Ecdysteroid molting hormone synthesis is directed by a pair of molting glands or Y-organs (YOs), and this synthesis is inhibited by molt-inhibiting hormone (MIH).
Mihika T. Kozma   +8 more
doaj   +1 more source

Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells

open access: yesAging Cell, EarlyView.
Healthy RPE cells produce AMPs and AMP precursors, including amyloid precursor protein (APP) and chemerin, and protect the neuroretina from blood‐borne pathogens and maintain homeostasis. When RPE cells undergo senescence, the antibacterial activity declines, and APP undergoes amylogenesis, leading to Aβ deposition.
Jian Liu   +7 more
wiley   +1 more source

RNAi of Neuropeptide CCHamide-1 and Its Receptor Indicates Role in Feeding Behavior in the Pea Aphid, Acyrthosiphon pisum

open access: yesInsects
Neuropeptide CCHamide-1 (abbreviated as CCHa1) is a recently discovered peptide that is present in many arthropods and is the ligand of the CCHa1R, a member of the G protein-coupled receptors (GPCRs) superfamily, which plays a regulatory role in diverse ...
Sohaib Shahid   +5 more
doaj   +1 more source

Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early‐life adversity

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman   +5 more
wiley   +1 more source

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