Results 101 to 110 of about 266,484 (376)

The evolution of neuropeptide signalling: insights from echinoderms

open access: yesBriefings in Functional Genomics, 2017
Neuropeptides are evolutionarily ancient mediators of neuronal signalling that regulate a wide range of physiological processes and behaviours in animals.
Dean C. Semmens, M. Elphick
semanticscholar   +1 more source

Ultrasound Controlled‐Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging

open access: yesAdvanced Science, EarlyView.
This study presents an ultrasound‐responsive hydrogel (MCF@CA) that co‐delivers a neuropeptide (CGRP) and a ROS‐scavenging manganese porphyrin to diabetic wounds. The system restores neuro‐immune communication, reprograms macrophages toward an anti‐inflammatory phenotype, and clears excess ROS, thereby accelerating wound closure and promoting mature ...
Mofan Li   +9 more
wiley   +1 more source

Evaluation of Dose-Dependent Effects of Nesfatin-1 in Pentyleneterazole Induced Seizures in Mice

open access: yesArchives of Epilepsy, 2021
Objectives: It is well known that neuropeptides have powerful modulator effects on inhibitory and excitatory systems in the brain. Serum nesfatin-1 levels are reported to be increased in epileptic patients and experimental models of epilepsy.
Özlem ERGÜL ERKEÇ
doaj   +1 more source

A role of corazonin receptor in larval-pupal transition and pupariation in the oriental fruit fly Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) [PDF]

open access: yes, 2017
Corazonin (Crz) is a neuropeptide hormone, but also a neuropeptide modulator that is internally released within the CNS, and it has a widespread distribution in insects with diverse physiological functions.
Chen, Er-Hu   +7 more
core   +2 more sources

Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution

open access: yesOpen Biology, 2016
Neuropeptides are evolutionarily ancient mediators of neuronal signalling in nervous systems. With recent advances in genomics/transcriptomics, an increasingly wide range of species has become accessible for molecular analysis.
Dean C. Semmens   +5 more
semanticscholar   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

open access: yesAdvanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl   +27 more
wiley   +1 more source

Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. [PDF]

open access: yes, 2012
BackgroundResponding to noxious stimuli by invoking an appropriate escape response is critical for survival of an organism. The sensations of small and large changes in temperature in most organisms have been studied separately in the context of ...
Ghosh, Rajarshi   +3 more
core   +3 more sources

Analytic framework for peptidomics applied to large-scale neuropeptide identification

open access: yesNature Communications, 2016
Large-scale mass spectrometry-based peptidomics for drug discovery is relatively unexplored because of challenges in peptide degradation and identification following tissue extraction.
A. Secher   +6 more
semanticscholar   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

open access: yesAdvanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren   +10 more
wiley   +1 more source

Neuropeptide Co-Release with Gaba May Explain Functional Non-Monotonic Uncertainty Responses in Dopamine Neurons [PDF]

open access: yes, 2007
Co-release of the inhibitory neurotransmitter GABA and the neuropeptide substance-P (SP) from single axons is a conspicuous feature of the basal ganglia, yet its computational role, if any, has not been resolved.
Bullock, Daniel, Tan, Can Ozan
core   +1 more source

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