Results 111 to 120 of about 260,956 (383)

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

bioRxiv, 2017
Neuropeptides are a diverse class of intercellular signaling molecules that mediate neuronal regulation of many physiological and behavioural processes.
Meet Zandawala, Ismail Moghul, L. A. Yañez Guerra, J. Delroisse, Nikara Abylkassimova, A. Hugall, T. O’hara, M. Elphick   +7 more
semanticscholar   +1 more source

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

A Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder

International Journal of Neuropsychopharmacology, 2017
Background Anxiety and trauma-related disorders are among the most prevalent and disabling medical conditions in the United States, and posttraumatic stress disorder in particular exacts a tremendous public health toll.
S. Sayed, N. V. Van Dam, S. Horn, Marin M. Kautz, M. Parides, S. Costi, K. Collins, B. Iacoviello, D. Iosifescu, A. Mathé, S. Southwick, A. Feder, D. Charney, J. Murrough   +13 more
semanticscholar   +1 more source

Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. [PDF]

, 2012
BackgroundResponding to noxious stimuli by invoking an appropriate escape response is critical for survival of an organism. The sensations of small and large changes in temperature in most organisms have been studied separately in the context of ...
Ghosh, Rajarshi, Kruglyak, Leonid, Mohammadi, Aylia, Ryu, William S   +3 more
core   +3 more sources

Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization

Angewandte Chemie International Edition, EarlyView.
Illuminating the Oxytocin Receptor: Here we present the development of fluorescent peptide tracers for the simultaneous visualization and activation of the oxytocin receptor, an important G protein‐coupled receptor involved in health and disease. These tracers are powerful new tools to support various imaging and functional studies across biological ...
Monika Perisic Böhm, Predrag Kalaba, Rachel S. Gormal, Maja Zupančič, Alexandra Wolf, Mia Juračić, Thomas Kremsmayr, Frédéric A. Meunier, Thierry Langer, Christian W. Gruber, Erik Keimpema, Markus Muttenthaler   +11 more
wiley   +1 more source

Urbilaterian origin of paralogous GnRH and corazonin neuropeptide signalling pathways

Scientific Reports, 2016
Gonadotropin-releasing hormone (GnRH) is a key regulator of reproductive maturation in humans and other vertebrates. Homologs of GnRH and its cognate receptor have been identified in invertebrates–for example, the adipokinetic hormone (AKH) and corazonin
Shi Tian, Meet Zandawala, Isabel Beets, Esra Baytemur, S. Slade, J. Scrivens, M. Elphick   +6 more
semanticscholar   +1 more source

Alpha‐calcitonin gene‐related peptide prevents pressure‐overload induced heart failure: role of apoptosis and oxidative stress

Physiological Reports, 2019
Alpha‐calcitonin gene‐related peptide (α‐CGRP) is a 37‐amino acid neuropeptide that plays an important protective role in modulating cardiovascular diseases.
Ambrish Kumar, Scott Supowit, Jay D. Potts, Donald J. DiPette   +3 more
doaj   +1 more source

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]

, 2013
It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin, Cyr, Nicole E., Litvinov, Bogdan Patedakis, Nillni, Eduardo A., Perello, Mario, Romero, Amparo, Stuart, Ronald C.   +6 more
core   +1 more source