Results 121 to 130 of about 266,484 (376)
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Aim To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001). Methods This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that
Takanobu Yamada +16 more
wiley +1 more source
At the crossroads of calcium signaling, protein synthesis and neuropeptide release
eLifeBy influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.
Jakob Rupert, Dragomir Milovanovic
doaj +1 more source
Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception
Toxins, 2015 Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the releases of various pain-modulating neurotransmitters, including ...
Dong-Wan Kim +2 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo +8 more
wiley +1 more source
Characteristics of Pruritus according to Morphological Phenotype of Psoriasis and Association with Neuropeptides and Interleukin-31 [PDF]
, 2020 Sung‐Min Park +5 more
openalex +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia +3 more
wiley +1 more source
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus [PDF]
, 2017 Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using autoradiographic, in situ ...
Borroto-Escuela, Dasiel +8 more
core
Sentience in cephalopod molluscs: an updated assessment
Biological Reviews, EarlyView.ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell +4 more
wiley +1 more source
Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience
Annals of the Child Neurology Society, EarlyView.ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf +9 more
wiley +1 more source