Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan+5 more
wiley +1 more source
Can serum neuropeptide levels help diagnose pediatric migraine? A prospective case–control study
Abstract Objective The objective of this study was to examine the serum levels of vasoactive neuropeptides (calcitonin gene‐related peptide [CGRP], pituitary adenylate cyclase‐activating peptide‐38 [PACAP‐38], substance P [SP], and vasoactive intestinal peptide [VIP], which have been linked to the pathophysiology of migraine in adults) in pediatric ...
Sibğatullah Ali Orak+8 more
wiley +1 more source
Target specificity of neuropeptide Y-immunoreactive cranial parasympathetic neurons [PDF]
G G Leblanc, SC Landis
openalex +1 more source
Abstract Objectives/Background Chronic migraine is a debilitating neurological disorder characterized by central sensitization and impaired brainstem habituation. OnabotulinumtoxinA is an established prophylactic treatment for chronic migraine, yet its effects on central trigeminal sensory processing remain incompletely understood.
Gerlinde Freimark+8 more
wiley +1 more source
Evaluation of the performance of ChatGPT‐4 and ChatGPT‐4o as a learning tool in endodontics
Abstract Aims The aim of this study was to evaluate the accuracy and consistency of responses given by two different versions of Chat Generative Pre‐trained Transformer (ChatGPT), ChatGPT‐4, and ChatGPT‐4o, to multiple‐choice questions prepared from undergraduate endodontic education topics at different times of the day and on different days ...
Esra Arılı Öztürk+2 more
wiley +1 more source
Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted Ladybird <i>Henosepilachna vigintioctopunctata</i>. [PDF]
Lei Q+9 more
europepmc +1 more source
Genetic Biomarkers for Periodontal Diseases: A Systematic Review
ABSTRACT Aims To identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease. Materials and Methods Following protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid ...
H. Dommisch+6 more
wiley +1 more source
Psychoneuroendocrine stress response in female and male youth with major depressive disorder
Background Exposure to psychosocial stress is one of the strongest risk factors for major depressive disorder (MDD) in youth, but underlying neurobiological mechanisms are poorly understood. Previous studies on the neuroendocrine stress response in youth with MDD are scarce, limited to cortisol, and rarely considered sex differences.
Anka Bernhard+5 more
wiley +1 more source
Changes in gene and protein expression related to feed intake and thermoregulation in broilers challenged with different doses of mixed Eimeria spp. [PDF]
Choi J, Lee J, Kim WK.
europepmc +1 more source
Abstract Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in premenopausal individuals with ovaries worldwide. Despite the diagnostic features of anovulation, ovarian cysts, and hyperandrogenemia, which indicate that ovary dysfunction is the cause of the syndrome, changes in central neuroendocrine circuits are a ...
Aleisha M. Moore
wiley +1 more source