Results 231 to 240 of about 266,484 (376)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Thyroid Response to Peripheral Endocrine Factors: Neuropeptide Y Influences Thyroid Function in the Reptile <i>Podarcis siculus</i>. [PDF]

Int J Mol Sci
Sciarrillo R, Lallo A, Carrella F, Gallicchio V, Mileo A, Valvano BS, De Falco M.   +6 more
europepmc   +1 more source

No fear no stress with neuropeptide S [PDF]

, 2012
Helmut L. Haas, Olga A. Sergeeva
openalex   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

, 2016
Cheryl Cero, Maria Razzoli, Ruijun Han, Bhavani S. Sahu, Jessica Patricelli, Zeng Guo, Nathan A. Zaidman, John J. Miles, Scott M. O’Grady, Alessandro Bartolomucci   +9 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

The Neuropeptide Neuroparsin-A Regulates the Establishment of Dominance Hierarchy in Bumblebees. [PDF]

Int J Mol Sci
Wang H, Liu Y, Mu X, Xu W, Liu H, Yong Q, Wang X, Zhai Y, Zheng H.   +8 more
europepmc   +1 more source

Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators

, 2017
Hui Ye, Jingxin Wang, Zichuan Tian, Fengfei Ma, James A. Dowell, Quentin Z. Bremer, Gaoyuan Lu, Brian A. Baldo, Lingjun Li   +8 more
openalex   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Neuropeptides, Altruism, and Adverse Childhood Experiences: Investigating Biological and Behavioral Correlations in Medical Students. [PDF]

Brain Sci
Khong J, Bennett L, Felix Rivera J, Andrews N, Vuong V, Zapata D, Khong P, Ryznar R.   +7 more
europepmc   +1 more source