Results 31 to 40 of about 114,817 (184)

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Role of the bed nucleus of the stria terminalis in feeding

Frontiers in Nutrition
As an important part of the limbic system of the forebrain, the bed nucleus of the stria terminalis (BNST) plays a key role in stress response, emotion regulation, and motivational behavior. Recent studies have demonstrated that BNST plays a crucial role
Keyan Wang, Wenbo Guo, Jiaxiang Xu, Yingjie Kuang, Xiqi Chen   +4 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

eLife
Insects have evolved a variety of neurohormones that enable them to maintain nutrient and osmotic homeostasis. Here, we characterized the ion transport peptide (ITP) signaling system in Drosophila.
Jayati Gera, Marishia Agard, Hannah Nave, Austin B Baldridge, Farwa Sajadi, Leena Thorat, Theresa H McKim, Shu Kondo, Dick R Nässel, Mitchell H Omar, Jean-Paul Paluzzi, Meet Zandawala   +11 more
doaj   +1 more source

Males, the Wrongly Neglected Partners of the Biologically Unprecedented Male–Female Interaction of Schistosomes

Frontiers in Genetics, 2019
Schistosomes are the only platyhelminths that have evolved separate sexes, and they exhibit a unique reproductive biology because the female’s sexual maturation depends on a constant pairing contact with the male.
Zhigang Lu, Zhigang Lu, Sebastian Spänig, Oliver Weth, Christoph G. Grevelding   +4 more
doaj   +1 more source

Neuroendocrine regulations in tissue-specific immunity: From mechanism to applications in tumor

Frontiers in Cell and Developmental Biology, 2022
Immune responses in nonlymphoid tissues play a vital role in the maintenance of homeostasis. Lots of evidence supports that tissue-specific immune cells provide defense against tumor through the localization in different tissue throughout the body, and ...
Si-Qing Liu, Bei Li, Juan-Juan Li, Si Sun, Sheng-Rong Sun, Qi Wu   +5 more
doaj   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

Frontiers in Neuroanatomy, 2021
Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon.
Isis Gil-Miravet, Aroa Mañas-Ojeda, Francisco Ros-Bernal, Esther Castillo-Gómez, Esther Castillo-Gómez, Hector Albert-Gascó, Andrew L. Gundlach, Francisco E. Olucha-Bordonau, Francisco E. Olucha-Bordonau   +8 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source