Results 61 to 70 of about 266,484 (376)

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core   +1 more source

Neuropeptide precursors and neuropeptides in the sea cucumber Apostichopus japonicus: a genomic, transcriptomic and proteomic analysis

Scientific Reports, 2019
The sea cucumber Apostichopus japonicus is a foodstuff with very high economic value in China, Japan and other countries in south-east Asia. It is at the heart of a multibillion-dollar industry and to meet demand for this product, aquaculture methods and
Muyan Chen, A. Talarovičová, Yingqiu Zheng, K. Storey, M. Elphick   +4 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evaluation of the SH-SY5Y cell line as an in vitro model for potency testing of a neuropeptide-expressing AAV vector

Frontiers in Molecular Neuroscience, 2023
Viral vectors have become important tools for basic research and clinical gene therapy over the past years. However, in vitro testing of vector-derived transgene function can be challenging when specific post-translational modifications are needed for ...
Jeanette Zanker, Daniela Hüser, Adrien Savy, Sara Lázaro-Petri, Eva-Maria Hammer, Christoph Schwarzer, Regine Heilbronn   +6 more
doaj   +1 more source

NPY Levels In Type 1 Diabetic Men of Different Duration. [PDF]

, 2011
Background: The aim of the present study was to evaluate whether the different duration of type 1 diabetes mellitus influences basal NPY secretion. Design: The NPY concentrations were measured in sixty-eight men with insulin-dependent diabetes mellitus ...
Anna Araldi, Claudio Giumelli, Lavinia Volpi, Luigi Capretti, Maria Grazia Magotti, Paolo Chiodera, Riccardo Volpi, Roberta Minelli, Simona Cataldo, Teore Ferri, Vittorio Coiro   +10 more
core   +1 more source

Global parameter search reveals design principles of the mammalian circadian clock [PDF]

, 2008
Background: Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle.
AC Liu, Achim Kramer, AT Winfree, BC Goodwin, D Gonze, D Somers, DB Forger, DB Forger, DK Welsh, ES Maywood, H Albus, H Kunz, Hanspeter Herzel, HD Piggins, James CW Locke, JC Dunlap, JC Leloup, JCW Locke, JCW Locke, JD Best, JE Quintero, JP Wisor, JS Griffith, K Vanselow, M Gallego, M Nagano, MC Antle, MH Hastings, MY Cheng, P Achermann, Pål O Westermark, RA Prosser, S Becker-Weimann, S Bernard, S Bornholdt, S Honma, S Yamazaki, SH Strogatz, SH Strogatz, SJ Aton, SJ Aton, SJ Kuhlman, TL To, VK Gribkoff, VM King, W Nakamura, Y Shigeyoshi   +46 more
core   +5 more sources

Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila

Nature Communications, 2017
Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly ...
M. Selcho, C. Millán, Angelina Palacios-Muñoz, Franziska Ruf, Lilian Ubillo, Jiangtian Chen, Gregor A. Bergmann, C. Ito, Valeria Silva, C. Wegener, J. Ewer   +10 more
semanticscholar   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, Accepted Article.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Modality-specific sensory integration and neuropeptide-mediated feedback facilitate mechano-nociceptive behavior in Drosophila

Nature Neuroscience, 2017
Nociception is an evolutionarily conserved mechanism to encode and process harmful environmental stimuli. Like most animals, Drosophila melanogaster larvae respond to a variety of nociceptive stimuli, including noxious touch and temperature, with ...
Chun Hu, Meike Petersen, Nina Hoyer, Bettina Spitzweck, F. Tenedini, Denan Wang, Alisa Gruschka, Lara S. Burchardt, E. Szpotowicz, M. Schweizer, A. Guntur, Chung-Hui Yang, P. Soba   +12 more
semanticscholar   +1 more source

Impact of Surface Functionalization on NV Quantum Properties: Implications for Biosensing with Fluorescent Nanodiamonds

Advanced Functional Materials, EarlyView.
Fluorescent nanodiamonds (fNDs) have emerged as an invaluable quantum sensing platform for biological and biochemical systems. This paper investigates the influence of common surface functionalization strategies for bioconjugation on the quantum properties of nitrogen vacancy (NV) centers in nanodiamonds.
Anja Sadžak, Iván Pérez, Mateja Guimarães, Lukas Spantzel, Fedor Jelezko, Michael Börsch, Anke Krueger   +6 more
wiley   +1 more source