Results 61 to 70 of about 88,878 (295)
Frontiers in Microbiology, 2019 Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut ...
Manpreet Bains +6 more
doaj +1 more source
Chapter 9 The neuropeptide concept
Maturitas, 1984 Publisher Summary Neuropeptides are endogenous substances present in nerve cells that are involved in nervous system function. Neuropeptides are synthesized in large precursor proteins, and several are formed in the same precursor such as adrenocorticotropic hormone (ACTH) and β-endorphin in proopiomelanocortin (POMC).
openaire +4 more sources
μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks
Annals of Neurology, EarlyView.Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim +6 more
wiley +1 more source
The Anatomical Record, EarlyView.Immunohistochemical staining for tyrosine hydroxylase reveals the neurons forming the locus coeruleus complex in the pontine region of the brain of the Congo gray parrot. The appearance and parcellation of the locus coeruleus complex in birds shows many similarities, but also differences to that observed in mammals.
Pedzisai Mazengenya, Paul R. Manger
wiley +1 more source
Molecules, 2020 Neuropeptides are released by neurons that are involved in a wide range of brain functions, such as food intake, metabolism, reproduction, and learning and memory.
Yang Zhu +6 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka +8 more
wiley +1 more source
Physics of Protein Aggregation in Normal and Accelerated Brain Aging
BioEssays, EarlyView.Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay +9 more
wiley +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Intestinal Barrier Glycosylation for Gut Physiology and Pathology
Barrier Immunity, EarlyView.ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley +1 more source
Gut‐microbiota‐brain Axis and post‐traumatic epilepsy
Epilepsia Open, EarlyView.Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley +1 more source