Results 61 to 70 of about 204,831 (332)

Neuroimmune Microenvironment Reprogramming via Immuno‐piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury

open access: yesAdvanced Materials, EarlyView.
A novel immuno‐piezoelectric transducer is innovatively developed. This device promotes neural stem cell (NSC) differentiation and maturation via ultrasound‐induced electrical stimulation and it amplifies the therapeutic efficacy of NSC in traumatic brain injury (TBI) by modulating the immune microenvironment. This piezoelectric transducer with “immune‐
Linlin Liang   +12 more
wiley   +1 more source

The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury

open access: yesPharmaceutics, 2021
Neuropathic pain is one of the most severe forms of chronic pain caused by the direct injury of the somatosensory system. The current drugs for treating neuropathies have limited efficacies or show important side effects, and the development of ...
Clara P. Falo   +9 more
doaj   +1 more source

Neuropeptide W [PDF]

open access: yesFrontiers in Endocrinology, 2012
Neuropeptide W (NPW), which was first isolated from the porcine hypothalamus, exists in two forms, consisting of 23 (NPW23) or 30 (NPW30) amino acids. These neuropeptides bind to one of two NPW receptors, either NPBWR1 (otherwise known as GPR7) or NPBWR2 (GPR8), which belong to the G protein-coupled receptor family.
Fumiko eTakenoya   +10 more
openaire   +3 more sources

Injectable Chitosan‐Platelet‐Rich Plasma Hybrid Biomaterial Improves Skin Wound Healing in Diabetic Rats

open access: yesAdvanced Therapeutics, EarlyView.
A biomaterial combining fresh platelet‐rich plasma with freeze‐dried chitosan (CS‐PRP) enhances diabetic skin wound healing in rats. CS‐PRP accelerates closure over the course of a month, improves healing tissue architecture and collagen remodeling, and sustains vascularization.
Laura Ahunon   +5 more
wiley   +1 more source

VEGF Axonal Transport Dependent on Kinesin-1B and Microtubules Dynamics

open access: yesFrontiers in Molecular Neuroscience, 2017
Axon-transport plays an important role in neuronal activity and survival. Reduced endogenous VEGF can cause neuronal damage and axon degeneration. It is unknown at this time if VEGF can be transported within the axon or whether it can be released by ...
Ping Yang   +6 more
doaj   +1 more source

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation [PDF]

open access: yes, 2016
Funding was provided by a Wellcome Trust ISSF starting grant (105625/Z/14/Z), Medical Research Scotland (PhD-719-2013), GW Pharmaceuticals (PhD-719-2013 - S.5242.001) and the BBSRC (BB/J012343/1).Peer reviewedPublisher ...
Hay, Elizabeth A   +3 more
core   +1 more source

Neuropeptides in tendinopathy [PDF]

open access: yesFrontiers in Bioscience, 2009
Overuse tendinopathy remains a major clinical burden for sports medicine and general practitioners. Recent studies have highlighted the role of sensory and autonomic nerves in generating or perpetuating the symptoms and tissue abnormalities associated with tendinopathy.
Alexander, Scott, Roald, Bahr
openaire   +2 more sources

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

open access: yesAdvanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang   +6 more
wiley   +1 more source

Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms

open access: yeseLife, 2014
Biological homeostasis invokes modulatory responses aimed at stabilizing internal conditions. Using tunable photo- and mechano-stimulation, we identified two distinct categories of homeostatic responses during the sleep-like state of Caenorhabditis ...
Stanislav Nagy   +6 more
doaj   +1 more source

Identification, Characterization, and Expression of a PRQFVamide-Related Peptide in Cephalopod Sepiella japonica

open access: yesFrontiers in Marine Science, 2022
Neuropeptides, as neurotransmitters and neuromodulators, have a variety of physiological functions in the mollusk. Here, a PRQFVamide-related peptide gene was cloned from cuttlefish Sepiella japonica (designated as SjPRQFVRP, GenBank Accession No ...
Jia-yin Qiu   +2 more
doaj   +1 more source

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