Results 111 to 120 of about 9,276,761 (294)

Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Fluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase,
Maxime Leprêtre   +3 more
wiley   +1 more source

Role of neuropeptide Y in development of valproate-induced eating behaviour disorder

open access: yesЭпилепсия и пароксизмальные состояния
Background. Eating behaviour disorder (EBD) induced by valproic acid (VPA) is one of the components of the pathogenesis of a serious complication of therapy with VPA and its salts such as VPA-induced metabolic syndrome (MetS).
N. A. Shnayder   +4 more
doaj   +1 more source

The Role of Magnesium in Liver Cirrhosis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Magnesium is a vital mineral involved in over 300 enzymatic reactions, crucial for physiological functions. Its deficiency, common in liver cirrhosis patients, correlates with poor outcomes by affecting inflammation, oxidative stress, fibrosis, and immunity. This review explores magnesium's role in cirrhosis and its interaction with disease mechanisms.
Weiye Zeng   +4 more
wiley   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

open access: yesRapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler   +7 more
wiley   +1 more source

Development of neuropeptide Y-ergic innervation of the small intestine in rats

open access: yesУчёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) acts as a neurotransmitter in the autonomic nervous system, including in the metasympathetic intramural ganglia of the intestine.
P.M. Masliukov   +3 more
doaj  

Formation of a β‐Endorphin Corona Mitigates Alzheimer's Amyloidogenesis

open access: yesSmall, EarlyView.
This study revealed the molecular mechanism of exercise‐induced β‐endorphin in suppressing the toxicity of Alzheimer's Aβ in vitro, in vivo and in silico. Abstract Senile plaques, comprised of nanosized aggregates of amyloid‐β (Aβ) peptides in the brain, are a pathological hallmark of Alzheimer's disease (AD).
Yunxiang Sun   +12 more
wiley   +1 more source

Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy

open access: yesVIEW, EarlyView.
The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang   +11 more
wiley   +1 more source

Acquired narcolepsy secondary to a presumptive hypothalamic hamartoma in a young German wirehaired pointer dog

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract A 3‐year‐old, male, entire, German wirehaired pointer dog was presented with a 2‐year history of paroxysmal episodes of collapse associated with reduced levels of consciousness. A magnetic resonance imaging study identified a single, ill‐defined, non‐contrast‐enhancing, intra‐axial mass lesion involving the hypothalamus.
Callum Atkins   +3 more
wiley   +1 more source

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