Results 141 to 150 of about 9,003,952 (365)

Cardiovascular Effects of Neuropeptide Y [PDF]

, 2017
Neuropeptide Y (NPY) is present in the brain, the adrenal medulla, and peripheral sympathetic nerves. This peptide is released together with catecholamines during sympathoadrenal activation.
Aubert, Jean-François, Brunner, Hans R., Corder, Roger, Evéquoz, Dominique, Gaillard, Rolf, Nussberger, Jürg, Waeber, Bernard   +6 more
core  

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]

, 2012
Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla, Sandeep Sharma, Yumei Zhuang   +2 more
core   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

SALMFamide salmagundi: The biology of a neuropeptide family in echinoderms [PDF]

, 2014
Ajayi, Aloyz, Beer, Bremaeker, Burke, Burns, Byrne, Byrne, Cisternas, Clarke, Cobb, Cobb, Conzelmann, Conzelmann, De Bremaeker, De Bremaeker, De Bremaeker, Du, Dupont, Díaz-Miranda, Díaz-Miranda, Díaz-Miranda, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Fujisawa, García-Arrarás, García-Arrarás, Ghyoot, Heinzeller, Heinzeller, Hewes, Hirokawa, Hoekstra, Jekely, Jorgensen, Lange, Mallefet, Maurice R. Elphick, Melarange, Melarange, Mirabeau, Mita, Mita, Moore, Moss, Nakano, Newman, Newman, Ohtani, Otara, Pentreath, Pisani, Price, Price, Primeaux, Rowe, Rowe, Semmens, Sodergren, Thorndyke, Tsutsui, Ubuka, Wegener, Yun, Yun   +71 more
core   +1 more source

Should We Consider Sacral Nerve Stimulation as a Treatment for Neurogenic Lower Urinary Tract Dysfunction? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To explore the boundary of clinical use of sacral nerve stimulation (SNS) in neurogenic lower urinary tract dysfunction (NLUTD), identifying barriers to approval and early‐impact research questions. Methods This review is derived from a proposal discussion at the International Consultation on Incontinence‐Research Society in Bristol in ...
Marcus J. Drake, Mathijs de Rijk, Stefania Musco, Jalesh Panicker, Michał Późniak, Nikita Bhatt, Brigitte Schurch   +6 more
wiley   +1 more source

Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction

, 2009
Yigang Wang, Dongsheng Zhang, Muhammad Ashraf, Tiemin Zhao, Wei Huang, Atif Ashraf, Ambikaipakan Balasubramaniam   +6 more
openalex   +2 more sources

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches

Obesity, EarlyView.
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers, Zachary L. Brown, Noureen S. Khalil, Stephen B. Haigh, Mitchell A. Shivers, Tej V. Patel, Austin T. Joshua, Neal L. Weintraub, Scott A. Barman, Eric J. Belin de Chantemele, Sergei A. Kirov, David W. Stepp, David J. R. Fulton   +12 more
wiley   +1 more source