Results 141 to 150 of about 9,276,761 (294)

Human Pulmonary Neuroendocrine Cells Respond to House Dust Mite Extract With PAR‐1 Dependent Release of CGRP

open access: yesAllergy, Volume 80, Issue 4, Page 976-985, April 2025.
This study aimed to develop and characterize an in vitro human PNEC model and investigated the neuroendocrine response to HDM extract. Exposure to HDM leads to dose‐dependent induction of the CGRP encoding gene, CALCB, and corresponding release of the neuropeptide.
Ritu Mann‐Nüttel   +4 more
wiley   +1 more source

The Direct and Indirect Role of IgE on Airway Epithelium in Asthma

open access: yesAllergy, Volume 80, Issue 4, Page 919-931, April 2025.
ABSTRACT Asthma is a chronic airway inflammatory disorder, affecting over 350 million people worldwide, with allergic asthma being the most common form of the disease. Allergic asthma is characterized by a type 2 (T2) inflammatory response triggered by numerous allergens beginning in the airway epithelium, which acts as a physical barrier to allergens ...
Christian Domingo   +7 more
wiley   +1 more source

Validity of Plasma Neuropeptide Y in Combination with Clinical Factors in Predicting Neuralgia Following Herpes Zoster

open access: yesInternational Journal of General Medicine
Dan Wu,1 Fang Li,2 Feifei Yang,3 Jun Liu4 1Department of Dermatology, Peking University First Hospital Ningxia Women and Children’s Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital), Yinchuan City, Ningxia Hui Autonomous Region,
Wu D, Li F, Yang F, Liu J
doaj  

Effects of glucagon‐like peptide 1 receptor agonists on testicular dysfunction: A systematic review and meta‐analysis

open access: yesAndrology, EarlyView.
Abstract Background Hypogonadism and infertility are two conditions that are heavily affected by overweight and obesity in the male patient. Glucagon‐like peptide 1 agonists (GLP‐1RAs) are a recently introduced class of antidiabetic drugs with powerful weight‐loss effect; this may induce an indirect positive effect on the testicular function ...
Gianmaria Salvio   +6 more
wiley   +1 more source

Misses and Near Misses in Paediatric Appendicitis: An Eight‐Year, Single‐Centre Retrospective Review

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Diagnostic error can result in the appendectomy of a normal appendix, commonly known as negative appendectomy (NA). Missed appendicitis (MA) is related to a poor outcome. The aim of this study was to determine whether there are factors in presentation associated with NA or MA.
Eric Scheier   +2 more
wiley   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf   +10 more
wiley   +1 more source

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