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2004
Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide YY (PYY), a circulating hormone released from gastrointestinal cells. Five subtypes of NPY receptors have been cloned, among which Y1, Y2and Y5 appear to be involved in the ...
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Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide YY (PYY), a circulating hormone released from gastrointestinal cells. Five subtypes of NPY receptors have been cloned, among which Y1, Y2and Y5 appear to be involved in the ...
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Microcirculatory Dynamics of Neuropeptide Y
Microvascular Research, 1994We used the hamster cheek pouch microcirculation to investigate by intravital microscopy the effects of neuropeptide Y (NPY) on arteriolar diameter, leukocyte adhesion to microvascular endothelium, and postcapillary venular permeability. We applied NPY topically for 3 min at concentrations of 10(-7), 10(-9), and 10(-11) M.
D, Kim +4 more
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Neuropeptide Y, ubiquitous and elusive
Peptides, 2004This paper reviews aspects of NPY research that were emerging in 1985, shortly after the isolation and characterization of the peptide. NPY had become known for its widespread distribution especially in the central and peripheral nervous systems, but also in the gastro-intestinal and respiratory tracts and in fibers innervating smooth muscle around ...
Bibie M, Chronwall, Zofia, Zukowska
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NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS
The Lancet, 1983Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic ...
T E, Adrian +6 more
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Neuropeptide Y receptor subtypes
Life Sciences, 1995Neuropeptide Y (NPY) is an amidated 36-amino acid peptide with a wide distribution in the central and peripheral nervous system. It can evoke numerous physiological responses by activating specific receptors. Studies using NPY analogs in various model systems and cell types demonstrate different orders of ligand potency and receptor binding affinity ...
C P, Wan, B H, Lau
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Metabolism and functions of neuropeptide Y
Neurochemical Research, 1996Neuropeptide Y is one of the most abundant neuropeptides in the central and peripheral nervous systems and its sequence is highly conserved among species. A number of key physiological roles for NPY are now emerging, especially in the control of feeding and energy homeostasis. Other physiological actions of NPY are also reviewed.
M dos S, Medeiros, A J, Turner
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NEUROPEPTIDE Y AND CARDIOVASCULAR REGULATION
Clinical and Experimental Pharmacology and Physiology, 1991SUMMARY1. The effects of neuropeptide Y (NPY) and related peptide fragments on blood pressure and vagal action at the heart were compared in the anaesthetized rat.2. A change in vagal action was taken as a measure of presynaptic activity and a change in blood pressure was taken as a measure of postsynaptic activity.3.
D I, McCloskey, E K, Potter
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Effects of Neuropeptide Y on Appetite
Mineral and Electrolyte Metabolism, 1999Neuropeptide Y (NPY) is a polypeptide containing 36 amino acids. Circulating NPY originates predominantly from the sympatho-adrenomedullary nervous system. It has a vasoconstrictive and mitogenic effect on blood vessels and seems to be involved in blood pressure regulation and angiogenesis.
F, Kokot, R, Ficek
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Neuropeptide Y in the dentate gyrus
2007Neuropeptide Y (NPY) is contained in at least four types of GABAergic interneurons in the dentate gyrus, many of which also contain somatostatin and give rise to the dense NPY innervation of the dentate outer molecular layer. In humans but not rats, minute amounts of NPY are also normally expressed in dentate granule cells, while seizure activity in ...
Günther, Sperk +2 more
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