Results 91 to 100 of about 21,634,263 (295)

Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling. [PDF]

BMC Cancer, 2023
Pascetta SA, Kirsh SM, Cameron M, Uniacke J.   +3 more
europepmc   +1 more source

Metabolic and serotonergic modulation of hypothalamic arcuate nucleus neurones in vitro [PDF]

1. The effects of glucose on the electrophysiological properties of rat hypothalamic arcuate nucleus (ARC) neurones were investigated. Neurones were recorded in 10 mM (hyperglycaemic) and 2 mM (euglycaemic) glucose-containing aCSF.
Saker, Louise
core  

Characterization of Receptor Types for Neuropeptide Y and Related Peptides

The structurally related peptides neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are neuronal and/ or endocrine messengers that are involved in a variety of physiological processes. NPY and PYY are able to evoke potent biological
Sheikh, Sören P, Wahlestedt, Claes, Grundemar, Lars   +2 more
core   +2 more sources

Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation. [PDF]

J Biol Chem, 2022
Medeiros PJ, Pascetta SA, Kirsh SM, Al-Khazraji BK, Uniacke J.   +4 more
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Investigação dos efeitos neuroprotetores da grelina e do neuropeptídeo Y em um modelo experimental da doença de Alzheimer [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2012.O acúmulo da proteína beta amilóide (AB) no sistema nervoso central (SNC) e os prejuízos cognitivos ...
Santos, Vanessa Valgas dos
core  

Identification of neuropeptide encoding transcripts, neuropeptide processing enzymes and neuropeptide F/Y G-protein coupled receptors in Fasciola hepatica

, 2020
Presented in this dataset are the high confidence neuropeptide-encoding transcripts identified in Fasciola hepatica, complete with signal peptide, neuropeptide, and basic cleavage site identification.
Wells, Duncan, School of Biological Sciences   +1 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

pH-dependent structural dynamics of neuropeptide Y in aqueous solution.

PLoS ONE
Neuropeptide Y regulates key molecular processes in the brain. Its interaction with the cell membrane, where it binds to specialized receptors with key physiological roles, likely depends on pH.
Hoa Thi Nguyen, Marc Spehr, Ana-Nicoleta Bondar, Paolo Carloni   +3 more
doaj   +1 more source

Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear. [PDF]

Mol Psychiatry, 2021
Bartsch JC, Jamil S, Remmes J, Verma D, Pape HC.   +4 more
europepmc   +1 more source