Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Obesity Reviews, EarlyView.ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati +12 more
wiley +1 more source
Oral Diseases, EarlyView.ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source
α-Latrotoxin and Pain: A Nociceptor Perspective on Latrodectism. [PDF]
Toxins (Basel)Davletov B +3 more
europepmc +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Neuropeptides in the Management of Alzheimer's Disease: From Pathophysiology to Therapeutic Opportunities. [PDF]
Int J Mol SciTiwari S +4 more
europepmc +1 more source
Illuminating Connections: Exploring the Dynamic Relationship Between Phototherapy and the Skin
Pediatric Dermatology, EarlyView.ABSTRACT The neonatal period represents a critical window for skin barrier maturation, microbial colonization, and immune development. As such, early‐life exposures may exert lasting effects on dermatologic and systemic health. A common early‐life exposure is blue light phototherapy (BLP), a life‐saving treatment for neonatal hyperbilirubinemia ...
Meshi Paz, Peter Lio
wiley +1 more source
Targeting the neuro-immune-skin axis: Advanced functional biomaterials for intelligent wound management and regeneration. [PDF]
Mater Today BioLi X +18 more
europepmc +1 more source
Depth of DNA photodamage in human corneas exposed to 222 nm or 254 nm UV
Photochemistry and Photobiology, EarlyView.Representative confocal 3D image of a section of a human cornea showing nuclei in blue (Hoechst 33342) and green, which was assigned to cells exhibiting Alexa555 conjugated to anti‐CPD antibody. The depth of photodamage was measured in Z‐stacks of the human corneal epithelium after exposure of the anterior surface to 50 or 100 mJ/cm2 at 222 or 254 nm ...
Manuela Buonanno +6 more
wiley +1 more source
Loss of Neuropeptide Y Signaling Accompanies the Neural-to-Mesenchymal Transcriptional Transition in Glioblastoma: A Multi-Scale Transcriptomic Analysis. [PDF]
Int J Mol SciArshad F +11 more
europepmc +1 more source