Results 111 to 120 of about 74,693 (295)

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

Comparative Analysis of Deep Learning‐Based Algorithms for Peptide Structure Prediction

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT While of primary importance in both the biomedical and therapeutic fields, peptides suffer from a relative lack of dedicated tools to predict efficiently and accurately their 3D structures despite being a crucial step in understanding their physio‐pathological function or designing new drugs. In recent years, deep‐learning methods have enabled
Clément Sauvestre, Jean‐François Zagury, Florent Langenfeld   +2 more
wiley   +1 more source

Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites [PDF]

, 2002
Mike Ludwig, Nancy Sabatier, Philip M. Bull, Rainer Landgraf, Govindan Dayanithi, Gareth Leng   +5 more
openalex   +1 more source

Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide‐susceptible and resistant strains

Pest Management Science, EarlyView.
Two small molecules, SACC‐0039590 and SACC‐0428788, killed cattle fever tick, R. microplus, susceptible Deutch strain and pyrethroid resistant Arauquita strain larvae. SACC‐0039590 at 1 mM decreased the reproductive parameters of Deutch females. Abstract BACKGROUND Resistance to acaricides underscores the need for tick control alternatives.
Waleed M. Arafa, Kimberly H. Lohmeyer, Patricia V. Pietrantonio   +2 more
wiley   +1 more source

Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility

Amino Acids
A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura borylation and Suzuki coupling methodology.
Maria Różanowska, Gabriela Szczupaj, Michał Nowakowski, Priyadharshni Rajagopal, Piotr F. J. Lipiński, Joanna Matalińska, Aleksandra Misicka, Marek Lisowski, Łukasz Jaremko, Mariusz Jaremko   +9 more
doaj   +1 more source

Prevention of Stress-Impaired Fear Extinction Through Neuropeptide S Action in the Lateral Amygdala [PDF]

, 2012
Frédéric Chauveau, Maren D. Lange, Kay Jüngling, Jörg Lesting, Thomas Seidenbecher, Hans‐Christian Pape   +5 more
openalex   +1 more source

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice

, 2009
Mickaël Decressac, Laetitia Prestoz, Julien Veran, Anne Cantereau, Mohamed Jaber, Afsaneh Gaillard   +5 more
openalex   +2 more sources

Neuropeptide Y receptor Y2 (NPY2R); NPY4R [PDF]

, 2011

openalex   +1 more source