Results 111 to 120 of about 73,747 (293)

Comparative Analysis of Deep Learning‐Based Algorithms for Peptide Structure Prediction

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT While of primary importance in both the biomedical and therapeutic fields, peptides suffer from a relative lack of dedicated tools to predict efficiently and accurately their 3D structures despite being a crucial step in understanding their physio‐pathological function or designing new drugs. In recent years, deep‐learning methods have enabled
Clément Sauvestre   +2 more
wiley   +1 more source

Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide‐susceptible and resistant strains

open access: yesPest Management Science, EarlyView.
Two small molecules, SACC‐0039590 and SACC‐0428788, killed cattle fever tick, R. microplus, susceptible Deutch strain and pyrethroid resistant Arauquita strain larvae. SACC‐0039590 at 1 mM decreased the reproductive parameters of Deutch females. Abstract BACKGROUND Resistance to acaricides underscores the need for tick control alternatives.
Waleed M. Arafa   +2 more
wiley   +1 more source

Neuropeptide proctolin in postural motoneurons of the crayfish [PDF]

open access: hybrid, 1984
CA Bishop, JJ Wine, Michael O’Shea
openalex   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

open access: yesRapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler   +7 more
wiley   +1 more source

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

open access: yesSensory Neuroscience, EarlyView.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan   +3 more
wiley   +1 more source

Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility

open access: yesAmino Acids
A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura borylation and Suzuki coupling methodology.
Maria Różanowska   +9 more
doaj   +1 more source

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