Results 181 to 190 of about 103,006 (298)

SemaGBA: A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley   +1 more source

The Parasitoid Wasp Glyptapanteles porthetriae Induces a Photoperiod‐Dependent Diapause‐Like State in Its Potential Overwintering Host Lasiocampa quercus

Entomologia Experimentalis et Applicata, EarlyView.
We evaluated Lasiocampa quercus as an overwintering host for the koinobiont larval endoparasitoid Glyptapanteles porthetriae by exposing parasitized larvae to different environmental conditions and comparing parasitoid development with that in the primary host Lymantria dispar.
Thomas Zankl, Christa Schafellner
wiley   +1 more source

In silico structural and docking models of dipteran FXPRLamide neuropeptides support ligand-receptor coevolution and suggest mechanisms for ligand bias. [PDF]

PLoS One
Farris SM.
europepmc   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source

The differences in local translatome across distinct neuron types is mediated by both baseline cellular differences and post-transcriptional mechanisms [PDF]

, 2018
Aryal, Shivani, Dougherty, Joseph D, Lagunas, Tomas, Lake, Allison M, Ouwenga, Rebecca   +4 more
core   +1 more source

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Gastroesophageal reflux-induced cough: the positive feedback loop of microaspiration and neurogenic inflammation. [PDF]

Ther Adv Respir Dis
Rui Y, Yi F, Lin MT, Lu H, Chen Y, Zhu H, Chen Z, Shen B.   +7 more
europepmc   +1 more source

Post‐marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective Calcitonin gene‐related peptide (CGRP) inhibitors, including monoclonal antibodies (mAbs) and small‐molecule antagonists (gepants), have transformed migraine treatment. Although clinical trials established their efficacy and initial safety, post‐marketing surveillance is essential for understanding their real‐world safety profile in ...
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Temporal regulation of macrophage polarization by abnormally innervated CGRP + Sensory nerves following spinal cord injury. [PDF]

Cell Mol Life Sci
Hu R, Lou Y, Wang L, He W, Ma X, Li X, Yue Z.   +6 more
europepmc   +1 more source

Delayed urticaria during treatment with anti‐CGRP monoclonal antibodies in migraine

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To characterize clinical presentation and management of urticaria associated with calcitonin gene‐related peptide (CGRP) ‐targeting monoclonal antibodies (mAbs) for migraine prophylaxis. Background CGRP‐targeting mAbs are effective in migraine prophylaxis, but have been associated with hypersensitivity reactions, including urticaria.
Christoph T. Berger, Federico Burguet Villena, Severin B. Vogt, Lukas Heydrich, Karin Hartmann, Athina Papadopoulou   +5 more
wiley   +1 more source