Results 61 to 70 of about 65,188 (311)
Advanced Science, EarlyView.Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen +14 more
wiley +1 more source
, 2017 The chapter considers past investigations of neuropeptides and their dysregulation in obsessive-compulsive disorder (OCD) and related conditions, and future directions for study.
Eric Hollander, Anahid Kabasakalian
core +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
Maturitas, 1984 In 1960/61 it was found that the release of adrenocorticotrophic hormone (ACTH) in response to emotional, but not to somatic or systemic stress, was diminished in rats in which the vasopressin storage organ, the posterior intermediate lobe of the rat pituitary, had been surgically removed [1,2].
openaire +4 more sources
, 2006 Obesity and development of the metabolic syndrome is related to an increased parasympathetic tone and hyperinsulinemia. We have now studied the effects of age and metabolic status on glucose-induced insulin release stimulated by the neuropeptides ...
Lindström, Per, +2 more
core +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Neuropeptides Phylogeny and Evolution
, 2009 Neuropeptides constitute a huge class of signaling molecules in the nervous system of many groups of animals. The phylogenetic relationships of neuropeptides have been difficult to determine across distantly related phyla because of their short amino ...
D. Larhammar, Larhammar, Dan,
core +1 more source
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
EFFECT OF FMRFAMIDE-LIKE PEPTIDES ON THE PHARYNGEAL MUSCLE OF NEMATODES
Российский паразитологический журнал, 2016 FMRFamide-like peptides play an important physiological role in the enteric nervous system of nematodes.This is confirmed by immunocytochemical data on the presence and localization of neuropeptides in the pharynx of parasitic nematode Ascaris suum ...
T. A. Maljutina, N. B. Terenina
doaj +1 more source
PLoS ONE, 2020 Neuropeptides are secreted molecules that have conserved roles modulating many processes, including mood, reproduction, and feeding. Dysregulation of neuropeptide signaling is also implicated in neurological disorders such as epilepsy.
Katherine A McCulloch +2 more
doaj +1 more source