Results 91 to 100 of about 28,987 (259)

Comparable Infection Risk of Ocrelizumab and Rituximab in Multiple Sclerosis in a Nationwide Swedish Cohort Study

Annals of Neurology, EarlyView.
In multiple sclerosis (MS), anti‐CD20 therapies have been associated with increased infection risk, but whether this risk differs between rituximab and ocrelizumab is not known. Using a nationwide cohort, we studied infection risk and relapse outcomes among 16,872 treatment episodes with rituximab, ocrelizumab, or other disease‐modifying therapies ...
Thomas Frisell, Sebastian Hedberg, Fredrik Piehl   +2 more
wiley   +1 more source

Application of abnormal muscle response and Z⁃L response combined monitoring during keyhole microvascular decompression of hemifacial spasm

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To compare the monitoring effect of abnormal muscle response (AMR) combined Z ⁃ L response (ZLR) and simple AMR in keyhole microvascular decompression (MVD) for hemifacial spasm (HFS).
YU Ju, GUAN Yan, XU Liang
doaj   +1 more source

Do consumers and healthcare professionals report the same adverse event differently? A paired analysis of duplicate vaccine safety reports in Norway

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus, Johaina Sarrage, Hilde Samdal, François Montastruc, Elena Rocca   +4 more
wiley   +1 more source

Homologous membrane wrapped ZIF‐8 nanoparticles accelerate differentiation of neural stem cell for spinal cord injury therapy

BMEMat, EarlyView.
Homologous membrane wrapped ZIF‐8 nanoparticles were proposed to improve biocompatibility and targeting ability to neural stem cells (NSCs). ZIF‐8‐SCM NPs exhibit pH responsiveness, thereby generating an intracellular Zn2+ storm to accelerate neural differentiation through calcium and MAPK signaling pathways. Moreover, they promote function recovery in
Jie Wang, Lusen Shi, Xinhui Liu, Zhong Zhuang, Zhichao Feng, Chunhui Sun, Jingang Wang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shuping Wang, Hengxing Zhou, Na Ren   +11 more
wiley   +1 more source

Intraoperative Neurophysiological Monitoring for Intradural Extramedullary Spinal Tumours

Global Spine Journal
Study Design Retrospective cohort study. Objectives Intraoperative neurophysiological monitoring (IONM) is widely used in spinal neurosurgery, particularly for intramedullary tumours.
Asfand Baig Mirza BSc (Hons), MBChB, MRCS (Eng), Amisha Vastani BSc (Hons), MBBS, Christoforos Syrris MBBS, MRCS (Ed), Timothy Boardman BSc, MBBS, Imran Ghani MBBS, Christopher Murphy MBChB, MSc, Axumawi Gebreyohanes MBBS, MRCS (Eng), Francesco Vergani MD, PhD, FRCS (SN), Ana Mirallave-Pescador MD, Jose P. Lavrador MD, Ahilan Kailaya Vasan FRCS (SN), Gordan Grahovac PhD, FRCS (SN)   +11 more
doaj   +1 more source

Wearable EEG Sensor Analysis for Cognitive Profiling in Educational Contexts

Sensors
Electroencephalography (EEG) provides a powerful means of capturing real-time neural activity, enabling the study of cognitive processes during complex learning tasks.
Eleni Lekati, Georgios N. Dimitrakopoulos, Konstantinos Lazaros, Panagiota Giannopoulou, Aristidis G. Vrahatis, Marios G. Krokidis, Panagiotis Vlamos, Spyridon Doukakis   +7 more
doaj   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Cervical Hyperextension Causes Acute Cerebral Congestion in Non-Anesthetized Healthy Adults: An Observational Self-Controlled Design Study

Medicina
Background and Objectives: Severe complications associated with cervical hyperextension during general anesthesia have been reported. The question is whether some of the cerebral/spinal ischemic complications could be partially related to the position ...
Ozlem Ersoy Karka, Derya Guclu, Ilknur S. Yorulmaz, Mehmet A. Sungur, Gizem Demir Senoglu, Gulbin Sezen, Yavuz Demiraran   +6 more
doaj   +1 more source

A guide to neuromodulation in drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh, Irena Dolezawa, Manu Hegde, Lukas Imbach, Brian N. Lundstrom, Francesca Pizzo, Vikram R. Rao, Jaysingh Singh, Derek Southwell, Satsuke Watanabe, Birgit Frauscher   +10 more
wiley   +1 more source

Inter‐rater reliability and clinical utility of the BASED score in infantile epileptic spasms syndrome

Epileptic Disorders, EarlyView.
Abstract Objective Hypsarrhythmia is the classical EEG pattern of children with infantile epileptic spasms syndrome (IESS). Multifocal spikes, slow waves of large amplitude, and chaoticity are its main characteristics, but these lack clear definitions, and the interrater reliability (IRR) is poor.
T. P. Cramer, B. Johnsen, V. S. Hansen, E. Qerama, T. S. Engedal   +4 more
wiley   +1 more source