Results 71 to 80 of about 31,045 (212)

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, EarlyView.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

Accelerated Brain Atrophy in Epilepsy: A Prospective Population‐Based Study

Annals of Neurology, EarlyView.
Objective Previous longitudinal neuroimaging studies suggest that epilepsy is a progressive disorder. To date, these findings have relied largely on populations from tertiary centers, resulting in ascertainment bias, as severely affected individuals are more likely to be rescanned.
Marian Galovic, Rebecca S. N. Liu, Alex D. Everitt, Robert Terziev, Louis Lemieux, Matthias J. Koepp, John S. Duncan   +6 more
wiley   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Effective Extraocular Muscle Monitoring for Cranial Nerves III and VI Using 25 mm Insulated Needle Electrodes: A Case Report

Korean Journal of Clinical Laboratory Science
In skull base surgery, preservation of the cranial nerve function of III and VI is an important consideration for maintaining the visual function and quality of life of patients. Nevertheless, intraoperative neurophysiological monitoring is not generally
Jae Seung BAEK, Sung Hyuk LIM, Min Hwan JANG, In Seok LEE, In Joong YOON, Eu Gene SON, Do Sung CHOI   +6 more
doaj   +1 more source

Cortical Thickness and White Matter Surface Morphology in Tourette Syndrome: A Cohort Study

Annals of Neurology, EarlyView.
Objective To examine cortical thickness and white matter surface morphology in a large sample of individuals with Tourette syndrome (TS) and neurotypical controls across the lifespan, and to assess associations with symptom severity, comorbidities, and medication use.
Sahar Delavari, Adam C. Frank, Ravi Bansal, Flora M. Vaccarino, Robert A. King, Paul Lombroso, Lawrence Scahill, James F. Leckman, Bradley S. Peterson   +8 more
wiley   +1 more source

Intraoperative Neurophysiological Monitoring in Cerebral Aneurysms Surgery

Неотложная медицинская помощь
Introduction The effectiveness of surgical treatment for cerebral aneurysms is due to the improvement of surgical and anesthetic methods that allow for the exclusion of aneurysms from the blood flow.
Z. A. Barbakadze, V. A. Lukyanchikov, M. V. Sinkin, V. A. Dalibaldyan, V. V. Krylov   +4 more
doaj   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Effects of an Inpatient Program on Medication Errors in Hospitalized People with Parkinson's Disease

Annals of Neurology, EarlyView.
Objective Hospitalized people with Parkinson's disease (PwP) face increased risks of medication errors and discharge to non‐home settings, both of which are associated with adverse outcomes. This study assessed differences in medication error rates and discharge outcomes before and after implementation of a dedicated inpatient program for hospitalized ...
Camila C. Piccinin, Jeryl Ritzi T. Yu, Victoria Stepanyants, Olivia Hogue, Claire Sonneborn, Anne Brooks, Patricia Clark, Shannon Shaffer, Laurie Moser, Tatiana Lopez‐Gonzalez, Brent S. Sokola, Kim Lewin, Roman Popov, Scott A. Sperling, Hubert H. Fernandez, Benjamin L. Walter   +15 more
wiley   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Perception of Neurologists on Intraoperative Neurophysiological Monitoring in Saudi Arabia

Acta Neurologica Taiwanica
Objective: Intraoperative neurophysiological monitoring (IONM) has the advantage of minimizing intraoperative neurological injury and limiting serious postoperative complications.
Hussein A. Algahtani, Bader H. Shirah, Yazeed K. Albeladi, Reyadh K. Albeladi   +3 more
doaj   +1 more source