Results 131 to 140 of about 200,218 (362)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

open access: yesHepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman   +4 more
wiley   +1 more source

Quantum Mechanics and the Cookie Cutter Paradigm [PDF]

open access: yesarXiv, 2000
What has so far prevented us from decrypting quantum mechanics is the Cookie Cutter Paradigm, according to which the world's synchronic multiplicity derives from surfaces that carve up space in the manner of three-dimensional cookie cutters. This insidious notion is shown to be rooted in our neurophysiological make-up. An effort is made to liberate the
arxiv  

Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort – Implications for NOTCH3 Variant‐Specific Disease Prediction

open access: yesAnnals of Neurology, EarlyView.
Objective Vascular NOTCH3 protein ectodomain aggregation is a pathological hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease typically caused by cysteine‐altering variants in NOTCH3.
Minne N. Cerfontaine   +10 more
wiley   +1 more source

Double gene mutations of LRSAM1 and REEP1 and a new REEP1 mutation site found in a patient with amyotrophic lateral sclerosis with subjective paresthesia: A case report

open access: yesIbrain, EarlyView., 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. Leucine‐rich repeats and sterility α mutations in motif 1 (LRSAM1) has been proven to be involved in the pathogenesis of ALS.
Ji‐Yao Qin   +6 more
wiley   +1 more source

Géométrie et cognition; l'exemple du continu [PDF]

open access: yesarXiv, 2008
In this paper I propose the idea to establish a clear distinction between the foundations of truth and the foundations of meaning in Mathematics. I explore on the most basic example, the mathematical line, the possibility that the foundations of its meaning are provided by a protomathematical object resulting from the identification by our perceptual ...
arxiv  

Effectiveness of Autologous Hematopoietic Stem Cell Transplantation versus Alemtuzumab and Ocrelizumab in Relapsing Multiple Sclerosis: A Single Center Cohort Study

open access: yesAnnals of Neurology, EarlyView.
Objective To compare clinical and radiological outcomes among relapsing multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT), alemtuzumab (ATZ), and ocrelizumab (OCR). Methods From a London (UK) hospital‐based observational cohort, modeled data were obtained from 621 relapsing–remitting multiple sclerosis ...
Paolo Antonio Muraro   +16 more
wiley   +1 more source

Polarization Theory of Motivations, Emotions and Attention [PDF]

open access: yesBulletin of Eastern-Siberian Scientific Center SB RAMS, 2005, No. 7, p.167-174 (in Russian), 2011
A new theory of motivations, emotions and attention is suggested, considering them as functions of sensory systems. The theory connects neurophysiological mechanisms of mental phenomena with the change of metabolic and functional state of perceptive neurons, which is reflected in the degree of polarization of a cell membrane.
arxiv  

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