Results 101 to 110 of about 93,816 (307)

Treadmill Exercise During Cerebral Hypoperfusion Has Only Limited Effects on Cognitive Function in Middle-Aged Subcortical Ischemic Vascular Dementia Mice

open access: yesFrontiers in Aging Neuroscience, 2021
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD).
Ryo Ohtomo   +16 more
doaj   +1 more source

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]

open access: yes, 2013
Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J.   +5 more
core   +1 more source

Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy [PDF]

open access: yes, 2020
Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke.
Chen, Ruoli   +4 more
core   +3 more sources

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song   +15 more
wiley   +1 more source

Sex differences in the role of AKAP12 in behavioral function of middle-aged mice

open access: yesBiology of Sex Differences
A-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules.
Hidehiro Ishikawa   +13 more
doaj   +1 more source

Chronic Cognitive Deficits and Associated Histopathology Following Closed-Head Concussive Injury in Rats

open access: yesFrontiers in Neurology, 2019
Close-head concussive injury, as one of the most common forms of traumatic brain injury (TBI), has been shown to induce cognitive deficits that are long lasting.
Ying Deng-Bryant   +8 more
doaj   +1 more source

Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning [PDF]

open access: yesConditioning Medicine, 2018, 2019
Acute neuroprotection in numerous human clinical trials has been an abject failure. Major systemic-and procedural-based issues have subsequently been identified in both clinical trials and preclinical animal model experimentation. As well, issues related to the neuroprotective moiety itself have contributed to clinical trial failures, including late ...
arxiv  

Preliminary Report: Cerebral blood flow mediates the relationship between progesterone and perceived stress symptoms among female club athletes after mild traumatic brain injury [PDF]

open access: yesarXiv, 2020
Female athletes are severely understudied in the field of concussion research, despite higher prevalence for injuries and tendency to have longer recovery time. Hormonal fluctuations due to normal menstrual cycle (MC) or hormonal contraceptive (HC) use have been shown to impact both post-injury symptoms and neuroimaging measures, but have not been ...
arxiv  

Perinatal neuroprotection [PDF]

open access: yesF1000Prime Reports, 2014
Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children.
Salmeen, Kirsten E.   +2 more
openaire   +2 more sources

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

open access: yesAdvanced Science, EarlyView.
A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao   +15 more
wiley   +1 more source

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