Results 81 to 90 of about 177,883 (410)

Diabetes exacerbates brain pathology following a focal blast brain injury: New role of a multimodal drug cerebrolysin and nanomedicine

, 2020
Blast brain injury (bBI) is a combination of several forces of pressure, rotation, penetration of sharp objects and chemical exposure causing laceration, perforation and tissue losses in the brain.
Patnaik, Ranjana,, Nozari, Ala,, Rudy J. Castellani, Sjoquist, Per-Ove,, Aruna Sharma, Castellani, Rudy J.,, Lars Wiklund, Lianyuan Feng, Muresanu, Dafin F.,, Per-Ove Sjöquist, Seaab Sahib, Sharma, Aruna,, Ala Nozari, Ranjana Patnaik, Dafin F. Muresanu, Tian, Z. Ryan,, Hari Shanker Sharma, Feng, Lianyuan,, Vicente Lafuente, Jose,, Z. Ryan Tian, Buzoianu, Anca D.,, Wiklund, Lars,, Sharma, Hari Shanker,, Anca D. Buzoianu, Sahib, Seaab,, José Vicente Lafuente   +25 more
core   +1 more source

Antioxidant Therapies for Neuroprotection—A Review

Journal of Clinical Medicine, 2019
Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between ...
R. Teleanu, Cristina Chircov, A. Grumezescu, A. Volceanov, D. Teleanu   +4 more
semanticscholar   +1 more source

The APCs of neuroprotection [PDF]

Journal of Clinical Investigation, 2009
Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant activated protein C (APC) is able to cross the blood-spinal cord barrier in mice and signal to both neuronal and non-neuronal cells ...
Charles T, Esmon, Jonathan D, Glass
openaire   +2 more sources

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease: a pilot study

Scientific Reports
The cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions.
Deborah Van Rossem, Gert-Jan Allemeersch, Nuno Barros, Joke Temmerman, Marijke Desmet, Ilka Ringoot, Annemie Ribbens, Veronique Michiels, Johan De Mey, Chris Baeken, Sebastiaan Engelborghs, Sara De Witte   +11 more
doaj   +1 more source

The Relevance and Implications of Monoclonal Antibody Therapies on Traumatic Brain Injury Pathologies

Biomedicines
Traumatic brain injury (TBI) is a global public health concern. It remains one of the leading causes of morbidity and mortality. TBI pathology involves complex secondary injury cascades that are associated with cellular and molecular dysfunction ...
Ping Wang, Starlyn Okada-Rising, Anke H. Scultetus, Zachary S. Bailey   +3 more
doaj   +1 more source

Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin

, 2020
Mild traumatic brain injury (mTBI) is one of the leading predisposing factors in the development of Parkinson's disease (PD). Mild or moderate TBI induces rapid production of tau protein and alpha synuclein (ASNC) in the cerebrospinal fluid (CSF) and in ...
Patnaik, Ranjana,, Sharma, Aruna,, Ala Nozari, Ranjana Patnaik, Dafin F. Muresanu, Tian, Z. Ryan,, Nozari, Ala,, Rudy J. Castellani, Hari Shanker Sharma, Aruna Sharma, Castellani, Rudy J.,, Lars Wiklund, Vicente Lafuente, Jose,, Z. Ryan Tian, Buzoianu, Anca D.,, Muresanu, Dafin F.,, Wiklund, Lars,, Sharma, Hari Shanker,, Anca D. Buzoianu, Sahib, Seaab,, José Vicente Lafuente, Seaab Sahib   +21 more
core   +1 more source

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons

, 2021
Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypoxic ...
Zhu, L, Chow, O, Singh, A, Astbury, K, Chen, R, Rose, E, Jenkins, S   +6 more
core   +1 more source

The emerging field of epigenetics in neurodegeneration and neuroprotection

Nature Reviews Neuroscience, 2017
Epigenetic mechanisms — including DNA methylation, histone post-translational modifications and changes in nucleosome positioning — regulate gene expression, cellular differentiation and development in almost all tissues, including the brain.
Jee-Yeon Hwang, Kelly A. Aromolaran, R. Zukin   +2 more
semanticscholar   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source