Results 81 to 90 of about 118,682 (313)

VIP-induced neuroprotection of the developing brain. [PDF]

open access: yes, 2011
International audienceExcitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits.
Sandrine Passemard   +7 more
core   +2 more sources

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao   +7 more
wiley   +1 more source

Neuroprotection From The Clinician\u27s Viewpoint: Myth Or Reality? [PDF]

open access: yes, 2007
Neuroprotection is a relatively new treatment strategy that targets the diseased cell and not the effects of the disease. Recently, there has been a tremendous interest in the 100s of drugs that are been tested in animal studies for potential use in ...
Swaraj Bose, MD
core  

Neuroprotection [PDF]

open access: yes, 2020
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the ...

core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

open access: yesAdvanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale   +6 more
wiley   +1 more source

Neuroprotection of hyperbaric oxygen treatment for traumatic brain injury involving autophagy pathway in rats [PDF]

open access: yes, 2017
Wen-Chao Liu, Liang Wen, Hao Wang, Jiang-Biao Gong, Tian-Xiang Zhan, Yuan-Yuan Meng, Xiao-Feng Yang Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China ...
Yang XF   +6 more
core  

Quantum Photothermal Self‐Monitoring Fiber Probes for In Vivo Photothermal Therapy

open access: yesAdvanced Science, EarlyView.
A miniaturized quantum photothermal fiber probe based on a metal/polymer/glass composite optoelectronic fiber that simultaneously guides lightwave and microwave was developed for the first time. The probe achieves enhanced photothermal conversion (13°C/mW, 25°C–120°C range) while providing real‐time self‐monitoring with 0.2°C thermal resolution at the ...
Wanjun Li   +12 more
wiley   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

open access: yesAdvanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang   +7 more
wiley   +1 more source

Prophylactic Neuroprotection to Improve Stroke Outcome [PDF]

open access: yes, 1994
The effort to develop therapies that improve outcome after acute ischemic stroke should bear fruit in the near future. The availability of effective, safe and economical neuroprotectants as a spin-off from this effort will lead to the evaluation of ...
Jonas, Saran   +2 more
core   +1 more source

Temporal Changes in Mitochondria-Centric Excitotoxic Responses Following Severe Penetrating Traumatic Brain Injury

open access: yesBiomedicines
Background/Objectives: Traumatic brain injury (TBI) remains a significant and urgent medical concern for the US military. TBI triggers excitotoxic responses immediately, involving mitochondrial dysfunction characterized by loss of calcium (Ca2+) cycling,
Hiren R. Modi   +3 more
doaj   +1 more source

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