Results 81 to 90 of about 132,339 (311)

Mitochondria-Associated mRNAs Restore ATP During Oxidative Stress via Cytosolic Translation

Antioxidants
Mitochondrial transplantation has been proposed as a strategy to restore cellular bioenergetics after oxidative injury, but the mechanisms governing ATP recovery remain unclear.
Dong-Bin Back, Gen Hamanaka, Ji-Hyun Park, Shin Ishikane, Masayoshi Tanaka, Takafumi Nakano, Yoshihiko Nakamura, Kazuhide Hayakawa   +7 more
doaj   +1 more source

Maximizing neuroprotection: where do we stand?

, 2012
Damien P KufflerInstitute of Neurobiology, University of Puerto Rico, San Juan, Puerto RicoAbstract: Brain and spinal cord traumas include blunt and penetrating trauma, disease, and required surgery.
Kuffler DP
core  

Study of red wine neuroprotection on astrocytes

, 2009
Phenolic composition of wine depends not only on the grape variety from which it is made, but on some external factors such as winemaking technology. Red wine possesses the most antioxidant effect because of its high polyphenolic content. The aim of this
Palomino Ruiz-Poveda, Olga María, Gómez-Serranillos Cuadrado, María Pilar, Martín, Sara, Ortega Hernández-Agero, María Teresa, Carretero Accame, María Emilia, Estrella, Isabel, Vacas, Visitación, Hernández, Teresa, Prodanov, Marín, Sara Martín, Marín Prodanov, Teresa Hernández, Visitación Vacas, Olga M. Palomino, Teresa Ortega, Isabel Estrella, M. Emilia Carretero, M. Pilar Gómez-Serranillos   +17 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system

Communications Biology
Crosstalk between central nervous system (CNS) and systemic responses is important in many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy, etc.
Ester Licastro, Giuseppe Pignataro, Jeffrey J. Iliff, Yanxiao Xiang, Eng H. Lo, Kazuhide Hayakawa, Elga Esposito   +6 more
doaj   +1 more source

Temporal Changes in Mitochondria-Centric Excitotoxic Responses Following Severe Penetrating Traumatic Brain Injury

Biomedicines
Background/Objectives: Traumatic brain injury (TBI) remains a significant and urgent medical concern for the US military. TBI triggers excitotoxic responses immediately, involving mitochondrial dysfunction characterized by loss of calcium (Ca2+) cycling,
Hiren R. Modi, Sudeep Musyaju, Anke H. Scultetus, Jignesh D. Pandya   +3 more
doaj   +1 more source

Neuroprotection and antioxidants

Neural Regeneration Research, 2016
Ischemia as a serious neurodegenerative disorder causes together with reperfusion injury many changes in nervous tissue. Most of the neuronal damage is caused by complex of biochemical reactions and substantial processes, such as protein agregation, reactions of free radicals, insufficient blood supply, glutamate excitotoxicity, and oxidative stress ...
Maria Lalkovicová, Viera Danielisová
openaire   +3 more sources

Orchestrated activation of mGluR5 and CB1 promotes neuroprotection [PDF]

, 2016
The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site ...
Alves-Silva, Juliana, Moreira, Fabricio A, Juliana Alves-Silva, Ribeiro, Fabiola M, Talita H. Ferreira-Vieira, Fabricio A. Moreira, Juliana G. Doria, Batista, Edleusa M L, Doria, Juliana G, Ferguson, Stephen S G, Stephen S. G. Ferguson, Ferreira-Vieira, Talita H, Fabiola M. Ribeiro, Edleusa M. L. Batista   +13 more
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Current status and future perspectives of pharmacological neuroprotection in visual system disorders

Purpose. To evaluate current pharmacological approaches to neuroprotection and identify promising directions for their development. Materials and Methods.
A.Yu. Safonenko, M.A. Shevchuk
core   +1 more source