Results 71 to 80 of about 177,883 (410)
Advanced Science, EarlyView.This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo +9 more
wiley +1 more source
Targeting NMDA receptors in stroke: new hope in neuroprotection
Molecular Brain, 2018 NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments.
Qiu Jing Wu, M. Tymianski
semanticscholar +1 more source
Archives of Neurology, 2007 The ability of pharmacological agents to limit secondary biochemical damage and cell death has been well established in numerous animal models of stroke, head injury, and spinal cord injury, yet the results of such neuroprotective treatment strategies in human injury have been disappointing.
Alan I, Faden, Bogdan, Stoica
openaire +2 more sources
Advanced Science, EarlyView.Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan +8 more
wiley +1 more source
Sex differences in the role of AKAP12 in behavioral function of middle-aged mice
Biology of Sex DifferencesA-kinase anchoring protein 12 (AKAP12) is a key scaffolding protein that regulates cellular signaling by anchoring protein kinase A (PKA) and other signaling molecules.
Hidehiro Ishikawa +13 more
doaj +1 more source
Frontiers in MedicineObjectiveThis study aims to develop a predictive model for tracheal tube sizes in adult double-lumen endotracheal intubation using radiomics and artificial intelligence (AI) technologies to enhance the safety and efficiency of intubation procedures ...
Shaopeng Ming +5 more
doaj +1 more source
L-Carnitine and acetyl-L-carnitine roles and neuroprotection in developing brain
Neurochemical Research, 2017 l-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. Treatment with l-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism.
G. C. Ferreira, M. McKenna
semanticscholar +1 more source
Perinatal neuroprotection [PDF]
F1000Prime Reports, 2014 Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children.
Salmeen, Kirsten E. +2 more
openaire +2 more sources
Advanced Science, EarlyView.Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao +12 more
wiley +1 more source
Neuroprotection induced by curcumin
Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells.
Antonietta Messina +8 more
core +1 more source