Results 71 to 80 of about 132,339 (311)

Neuroprotection in the treatment of acute ischemic stroke [PDF]

, 2017
Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability to protect the ischemic brain from injury until reperfusion and then to protect the brain from reperfusion injury could theoretically improve freedom from ...
Rajan A.G. Patel, Patel, Rajan A. G., McMullen, Paul W., Paul W. McMullen   +3 more
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Anesthetic Neuroprotection in Experimental Stroke in Rodents

, 2017
Background Patients undergoing endovascular therapy for acute ischemic stroke may require general anesthesia to undergo the procedure. At present, there is little clinical evidence to guide the choice of anesthetic in this acute setting.
Andrew M. Walker, Ramana M. Appireddy, Sarah K. McCann, Joanna J. Moser, David P. Archer   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Rethinking neuroprotection in severe traumatic brain injury : toward bedside neuroprotection [PDF]

, 2017
Neuroprotection after traumatic brain injury (TBI) is an important goal pursued strenuously in the last 30 years. The acute cerebral injury triggers a cascade of biochemical events that may worsen the integrity, function, and connectivity of the brain ...
F. Ortolano, M. Carbonara, Sandra Magnoni, Fabrizio Ortolano, Tommaso Zoerle, S. Magnoni, Nino Stocchetti, T. Zoerle, E. R. Zanier, Giulio Bertani, Marco Carbonara, N. Stocchetti, Elisa R. Zanier, G. Bertani, Ortolano F., Carbonara M., Zoerle T., Zanier E. R., Stocchetti N., Bertani G., Magnoni S.   +20 more
core   +2 more sources

Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin

, 2020
Mild traumatic brain injury (mTBI) is one of the leading predisposing factors in the development of Parkinson's disease (PD). Mild or moderate TBI induces rapid production of tau protein and alpha synuclein (ASNC) in the cerebrospinal fluid (CSF) and in ...
Patnaik, Ranjana,, Sharma, Aruna,, Ala Nozari, Ranjana Patnaik, Dafin F. Muresanu, Tian, Z. Ryan,, Nozari, Ala,, Rudy J. Castellani, Hari Shanker Sharma, Aruna Sharma, Castellani, Rudy J.,, Lars Wiklund, Vicente Lafuente, Jose,, Z. Ryan Tian, Buzoianu, Anca D.,, Muresanu, Dafin F.,, Wiklund, Lars,, Sharma, Hari Shanker,, Anca D. Buzoianu, Sahib, Seaab,, José Vicente Lafuente, Seaab Sahib   +21 more
core   +1 more source

Nanodelivery of oxiracetam enhances memory, functional recovery and induces neuroprotection following concussive head injury

, 2021
Military personnel are the most susceptible to concussive head injury (CHI) caused by explosion, blast or missile or blunt head trauma. Mild to moderate CHI could induce lifetime functional and cognitive disturbances causing significant decrease in ...
Nozari, Ala, Preeti K. Menon, Castellani, Rudy J., Rudy J. Castellani, Menon, Preeti K.,, Aruna Sharma, Wang, Zhenguo, Lars Wiklund, Muresanu, Dafin F., Lianyuan Feng, Lafuente, José Vicente, Patnaik, Ranjana, Vicente Lafuente, José, Seaab Sahib, Sharma, Hari Shanker, Sahib, Seaab, Niu, Feng, Buzoianu, Anca D., Sharma, Aruna,, Ala Nozari, Ranjana Patnaik, Feng Niu, Dafin F. Muresanu, Sharma, Aruna, Menon, Preeti K., Wiklund, Lars, Hari Shanker Sharma, Feng, Lianyuan, Z. Ryan Tian, Tian, Z. Ryan, Wiklund, Lars,, Sharma, Hari Shanker,, Anca D. Buzoianu, José Vicente Lafuente, Zhenguo Wang   +34 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source