Results 71 to 80 of about 118,682 (313)
BiomedicinesTraumatic brain injury (TBI) is a global public health concern. It remains one of the leading causes of morbidity and mortality. TBI pathology involves complex secondary injury cascades that are associated with cellular and molecular dysfunction ...
Ping Wang +3 more
doaj +1 more source
Biointegrated Battery‐Based Electroceuticals
Advanced Materials, EarlyView.Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou +6 more
wiley +1 more source
Scientific ReportsThe cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions.
Deborah Van Rossem +11 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Advanced Science, EarlyView.Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez +16 more
wiley +1 more source
Rethinking Neuroprotection in Severe Traumatic Brain Injury: Toward Bedside Neuroprotection [PDF]
, 2017 Neuroprotection after traumatic brain injury (TBI) is an important goal pursued strenuously in the last 30 years. The acute cerebral injury triggers a cascade of biochemical events that may worsen the integrity, function, and connectivity of the brain ...
F. Ortolano +13 more
core +3 more sources
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Frog-derived peptides and neuroprotection [PDF]
The incidence of age-related diseases (e.g., neurodegenerative diseases) is increasing as the world’s population lives longer. Neurodegeneration, the dysfunction and loss of neurons, is a hallmark of chronic (e.g., Alzheimer’s disease and Parkinson’s ...
Moreira, Daniel C. +2 more
core +1 more source
New possibilities of neuroprotection in ischemic stroke [PDF]
, 2011 Reperfusion and neuroprotection are two present-day therapy strategies for patients with acute stroke. The paper reviews currently available drugs used for neuroprotection in ischemic strokes in the context of evidence-based ...
D. V. Sergeyev +5 more
core +2 more sources
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source