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Neuroprotective agents: Cannabinoids
Clinical Immunology, 2012Chronic inflammation and neurodegeneration are the main pathological traits of multiple sclerosis that coexist in all stages of the disease course, with complex and still nonclarified relationships. Currently licensed medications have efficacy to control aspects related to inflammation, but have been unable to modify pure progression. Experimental work
Antonio García-Merino, Antonio Sánchez
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, 2020
With the advent of medical cannabis usage globally, there has been a renewed interest in exploring the chemical diversity of this unique plant. Cannabis produces hundreds of unique phytocannabinoids, which not only have diverse chemical structures but ...
Dylan T Marsh, S. Smid
semanticscholar +1 more source
With the advent of medical cannabis usage globally, there has been a renewed interest in exploring the chemical diversity of this unique plant. Cannabis produces hundreds of unique phytocannabinoids, which not only have diverse chemical structures but ...
Dylan T Marsh, S. Smid
semanticscholar +1 more source
Physical Medicine and Rehabilitation Clinics of North America, 1999
Although basic research has revealed many mechanisms involved in the repair or elimination of damaged neurons, turning these mechanisms into clinically useful neuroprotective interventions is a slow process. Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides ...
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Although basic research has revealed many mechanisms involved in the repair or elimination of damaged neurons, turning these mechanisms into clinically useful neuroprotective interventions is a slow process. Numerous neurotrophic factors seem to mediate neuronal repair and viability, but because the neurotrophic factors are proteins or polypeptides ...
openaire +2 more sources
2,5-Diketopiperazines as Neuroprotective Agents
Mini-Reviews in Medicinal Chemistry, 20122,5-diketopiperazines are the simplest cyclic peptides found in nature, commonly biosynthesized from amino acids by different organisms, and represent a promising class of biologically active natural products. Their peculiar heterocyclic structure confers high stability against the proteolysis and constitutes a structural requirement for the active ...
CORNACCHIA, CATIA +5 more
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Leptin as a neuroprotective agent
Biochemical and Biophysical Research Communications, 2008Leptin is a hormone produced by adipocytes that regulates satiety (food uptake) and energy homeostasis by activating receptors expressed in neurons of the hypothalamus. Leptin receptors are also found in other brain regions such as the hippocampus and cerebral cortex, and have known roles in regulating neural development and neuroendocrine functions ...
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GV150526: A Neuroprotective Agent
CNS Drug Reviews, 2000ABSTRACTThromboembolic stroke is a severe, disabling disease characterized by an abrupt reduction of cerebral blood flow, which leads to deprivation of oxygen and nutrients to neuronal tissue, followed by permanent brain damage. Evidence has been accumulated to implicate excitotoxicity in the pathogenesis of ischemic brain injury.
Andrea Terron +4 more
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Neuroprotective Agents as an Adjuvant Treatment in Patients With Acute Spinal Cord Injuries
Clinical Spine Surgery, 2019Study Design: This was a systematic literature review. Objective: The objective of this study was to evaluate randomized clinical trials that address potential neuroprotective agents used to improve neurological outcome in patients with spinal cord ...
A. Joaquim +3 more
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Caspase inhibitors as neuroprotective agents
Emerging Drugs, 2001Apoptotic neuronal cell death has been demonstrated to occur in the central nervous system (CNS), following both acute injury and during chronic neurodegenerative conditions. Currently, the majority of experimental evidence for a role of caspases in CNS damage has been established following acute neuronal insults, including ischaemic stroke, traumatic ...
Jeffrey J. Legos +2 more
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Metabolomic Study of Hibernating Syrian Hamster Brains: In Search of Neuroprotective Agents.
Journal of Proteome Research, 2019Syrian hamsters undergo a reversible hyperphosphorylation of protein τ during hibernation, providing a unique natural model that may unveil the physiological mechanisms behind this critical process involved in the development of Alzheimer's disease and ...
C. González-Riaño +5 more
semanticscholar +1 more source
Neuroprotective effects of anesthetic agents
Journal of Anesthesia, 2005Ischemic neuronal injury is characterized by early death mediated by excitotoxicity and by delayed death caused by apoptosis. Current evidence indicates that volatile agents, barbiturates, and propofol can protect neurons against ischemic injury caused by excitotoxicity.
Piyush M. Patel +2 more
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