Results 181 to 190 of about 114,586 (238)

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Acetylcholinesterase Inhibition and Antioxidant Activity of DHA‐Disubstituted Phospholipids

Molecular Nutrition &Food Research, EarlyView.
1,2‐Di‐DHA‐PC phospholipids in nutraceutical form may cross the blood‐brain barrier and inhibit acetylcholinesterase (AChE) activity, with an efficacy similar to galantamine. This suggests their potential as neuroprotective agents in the treatment of Alzheimer's disease.
Ernestina Garcia‐Quinto, Sabrina Sollecito‐Rovella, Victor M. Amador‐Luna, Lidia Montero, Gloria Fernandez‐Lorente   +4 more
wiley   +1 more source

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Molecular Nutrition &Food Research, EarlyView.
Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García, Begoña Ayuda‐Durán, Susana González‐Manzano, Celestino Santos‐Buelga, Ana M. González‐Paramás   +4 more
wiley   +1 more source

Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases

Neuroprotection, EarlyView.
The abstract depicts the gut‐brain axis, illustrating the bidirectional communication between the gastrointestinal tract and the central nervous system. Probiotics can induce the production of neurotrophins, neurotransmitters, SCFAs, and contribute to increased antioxidant levels, which can benefit brain health. In contrast, antibiotics can disrupt the
Tobiloba S. Olajide, Omamuyovwi M. Ijomone   +1 more
wiley   +1 more source

Novel PPAR-γ agonists as potential neuroprotective agents against Alzheimer's disease: rational design, synthesis, in silico evaluation, PPAR-γ binding assay and transactivation and expression studies. [PDF]

RSC Adv
D P, Hani U, Haider N, Talath S, Shanmugarajan D, P P, P A, Prashantha Kumar BR.   +7 more
europepmc   +1 more source

Minocycline and Magnesium As Neuroprotective Agents for Ischemic Stroke: A Systematic Review. [PDF]

Cureus, 2020
Ortiz JF, Ruxmohan S, Saxena A, Morillo Cox Á, Bashir F, Tambo W, Ghani MR, Moya G, Córdova I.   +8 more
europepmc   +1 more source

Hydrogen, the Next Neuroprotective Agent? [PDF]

Future Neurology, 2019
openaire   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

One‐Pot Gram‐Scale Synthesis of Cynandione A and Detailed Mechanistic Insights into its Regioselectivity

ChemistryOpen, EarlyView.
An improved one‐pot, gram‐scale synthesis of cynandione A, a key natural product from Cynanchi wilfordii Radix with diverse biological activities, has been developed. DFT calculations clarified the regioselectivity of the arylation step in the benzoquinone, revealing that the C3 position of the nucleophile is highly favored due to both kinetic and ...
Jun Sung Kang, Jin Yi Jung, Chan Jae Cho, Seoungwoo Kang, Yeonjoon Kim, Jae Hyun Kim   +5 more
wiley   +1 more source

Synthesis of α-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents. [PDF]

ChemMedChem, 2020
Jastaniah A, Gaisina IN, Knopp RC, Thatcher GRJ.   +3 more
europepmc   +1 more source