Results 141 to 150 of about 375,184 (254)

An ETH‐LAD trip with unfavourable consequences: A case report

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler   +6 more
wiley   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor   +11 more
wiley   +1 more source

Unsupervised machine learning for multi‐system adverse event pattern detection in pharmacovigilance: A proof‐of‐concept analysis of fluoroquinolone reports in FAERS

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
. Aims Traditional pharmacovigilance detects single drug–event associations but cannot readily characterize multi‐system adverse‐event patterns such as fluoroquinolone‐associated disability. We evaluated unsupervised machine learning for this purpose, using fluoroquinolones as an exemplar.
Niaz Chalabianloo   +3 more
wiley   +1 more source

Neuropsychiatry Case Studies [electronic resource] /

open access: yes
This book comprises succinct, accessible clinical cases in neuropsychiatry. Each clinical case has a specific and practical learning point, concerned with assessment, diagnosis, treatment or general approach. Each case models clinical reasoning and shows
Rickards, Hugh.editor.edthttp://id.loc.gov/vocabulary/relators/edt   +2 more
core   +1 more source

Systematic review of clinical trials and cohort studies evaluating HIV post‐exposure prophylaxis (PEP) regimens to inform updated Canadian guidelines

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Background We conducted a systematic review of clinical trials and cohort studies on HIV post‐exposure prophylaxis (PEP) regimens to inform updated 2025 Canadian guidelines. Methods We searched Medline and Embase (July 2017–June 2024) for studies reporting on: HIV acquisition, PEP completion, adverse events (AEs) leading to discontinuation and/
Stanley O. Onyegbule   +12 more
wiley   +1 more source

Exploring the early observations of parents supporting their children with school attendance problems (SAPs): A co‐produced study

open access: yesBritish Educational Research Journal, EarlyView.
Abstract School Attendance Problems (SAPs) represent a significant challenge requiring early identification and intervention. Current service provision often does not recognise early indicators that parents observe, creating gaps between when initial concerns are raised and formal support is provided.
Tereza Aidonopoulou‐Read   +4 more
wiley   +1 more source

Probiotic spore‐based bioresponsive drug delivery for reversing inflammatory bowel disease and its associated anxiety and depression

open access: yesBMEMat, EarlyView.
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song   +9 more
wiley   +1 more source

What's a White Matter ‘Fiber’?

open access: yesClinical Anatomy, EarlyView.
ABSTRACT White matter anatomy is investigated using methods that operate at markedly different spatial scales and rely on distinct biological and physical principles. Nevertheless, the term “fiber” is routinely applied to the outputs of tract‐tracing studies, diffusion MRI tractography, and postmortem fiber dissection, often as though these entities ...
Guillaume Dannhoff   +3 more
wiley   +1 more source

Prefrontal Planning Latency Associated With Age and Serological Evidence of Microbial Exposure

open access: yesChronic Diseases and Translational Medicine, EarlyView.
Planning latency versus age by group. Scatterplot showing individual observations (n = 53) stratified by fibromyalgia status. LOESS smoothing curves with 95% confidence intervals (shaded regions) illustrate the relationship within each group. Overall, rₛ = 0.394 (p = 0.003).
Basant K. Puri   +4 more
wiley   +1 more source

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