Results 31 to 40 of about 795,270 (294)

Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells

iScience, 2019
Summary: We report that cerebrum-specific inactivation of the histone deacetylase 3 (HDAC3) gene causes striking developmental defects in the neocortex, hippocampus, and corpus callosum; post-weaning lethality; and abnormal behaviors, including ...
Lin Li, Jianliang Jin, Xiang-Jiao Yang
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Correction: Neumeier et al. The Loneliness of Migraine Scale: A Development and Validation Study. Clin. Transl. Neurosci. 2022, 6, 12

Clinical and Translational Neuroscience
The Clinical and Translational Neuroscience Editorial Office would like to make the following correction to the Academic Editor listed on this published paper [...]
Clinical and Translational Neuroscience Editorial Office
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Neuroscience Literacy and Academic Outcomes: Insights from a University Student Population

Brain Sciences
Background/Objectives: There is growing interest in neuroscience-informed education, as well as neuroscience-derived strategies that maximise learning.
Abeer F. Almarzouki, Arzan I. Alqahtani, Jumana K. Baessa, Dhuha K. Badaood, Rwdyn R. Nujoom, Raneem W. Malibari, Elaf M. Aljared, Reema S. Alghamdi   +7 more
doaj   +1 more source

Kajian Neuroscience dalam Pengembangan Ilmu Sekolah Dasar

Jurnal Inovasi Pendidikan dan Pembelajaran Sekolah Dasar, 2020
This article aims to explain the implementation of neuroscience studies in the development of science in elementary schools. The method of writing this article is literature study by exploring various scientific papers related to this topic.
Rizky Amelia, Kus Eddy Sartono, Chairil Faif Pasani   +2 more
doaj   +1 more source

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi, Marie A. Engh, Tamás Kói, Zsolt Molnár, Gábor Csukly, Klaudia Horváth, Emma Hargitai, Péter Hegyi, Zsolt Mezei   +8 more
wiley   +1 more source

Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis

iScience, 2019
Summary: Learning to perceptually discriminate between chemical signals in the environment (olfactory perceptual learning [OPL]) is critical for survival.
Arielle Schilit Nitenson, Gabriela Manzano Nieves, Devon Lynn Poeta, Ryan Bahar, Carolyn Rachofsky, Nathalie Mandairon, Kevin G. Bath   +6 more
doaj   +1 more source

The selective allure of neuroscientific explanations. [PDF]

PLoS ONE, 2014
Some claim that recent advances in neuroscience will revolutionize the way we think about human nature and legal culpability. Empirical support for this proposition is mixed.
Nicholas Scurich, Adam Shniderman
doaj   +1 more source

Menelusuri Jejak Otak dan ‘Aql Dalam Alquran Perspektif Neurosains dan Pendidikan Islam di Era Pandemi Covid-19

Tadris: Jurnal Pendidikan Islam, 2021
The purpose of this research analyzing Islamic education learning in the era of the Covid-19 pandemic from the perspective of Neuroscience. The development of the learning model of Islamic education and neuroscience in this modern era is in line with ...
Mohammad Jailani, Suyadi, Dedi Djubaedi
doaj   +1 more source