Results 61 to 70 of about 5,802 (234)

A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion. [PDF]

PLoS Computational Biology, 2013
Neurotransmitter release depends on the fusion of secretory vesicles with the plasma membrane and the release of their contents. The final fusion step displays higher-order Ca(2+) dependence, but also upstream steps depend on Ca(2+).
Alexander M Walter, Paulo S Pinheiro, Matthijs Verhage, Jakob B Sørensen   +3 more
doaj   +1 more source

The T‐Type Calcium Channel CACNA1H is Required for Smooth Muscle Cytoskeletal Organization During Tracheal Tubulogenesis

Advanced Science, Volume 11, Issue 44, November 26, 2024.
Defects in the T‐type calcium channel CACNA1H cause defects in airway smooth muscle formation and its cytoskeletal organization in tracheal stenosis, and pharmacological increase of RhoA activity can partially attenuate these defects in mice. Analysis of human tracheal tissues suggests that a decrease in CACNA1H proteins is associated with tracheal ...
Ziying Liu, Chunyan Lu, Li Ma, Changjiang Li, Haiyun Luo, Yiqi Liu, Xinyuan Liu, Haiqing Li, Yachao Cui, Jiahang Zeng, Natalia Bottasso‐Arias, Debora Sinner, Le Li, Jian Wang, Didier Y. R. Stainier, Wenguang Yin   +15 more
wiley   +1 more source

Current Concepts in the Field of Neurochemical Mediation [PDF]

, 1969
Chemical mediators involved in the integrative activities of the nervous system operate either at close range as neurohumors or over some distance as neurohormones. As will become evident, the distinction between neurohumoral and neurohormonal activities
Scharrer, Berta
core   +1 more source

Synaptophysin and synaptoporin expression in the developing rat olfactory system [PDF]

, 1993
The expressions of two closely related synaptic vesicle antigens synaptophysin and synaptoporin were examined in the olfactory system of the adult rat and during pre- and postnatal development.
Bayer, Bergmann, Betz, Bixby, Breipohl, Brunjes, Elferink, Farbman, Farbman, Fletcher, Geppert, Gesteland, Graziadei, Halász, Halász, Hinds, Hsu, Huttner, Jahn, Jahn, Knaus, Kosaka, Lahr, Lahr, Leube, Mandell, Marchand, Margolis, Marquèze-Pouey, Matteoli, McLean, Navone, Ovtscharoff, Pedersen, Rehn, Schwob, Schwob, Shipley, Smotherman, Specht, Specht, Südhof, Thomas, Thomas, Tixier-Vidal, Trimble, Van Lookeren Campagne, Verhaagen, Wendland, Wiedenmann, Zhong   +50 more
core   +1 more source

A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity

Alzheimer's &Dementia, Volume 20, Issue 11, Page 8012-8027, November 2024.
Abstract INTRODUCTION In the aging brain, cognitive abilities emerge from the coordination of complex pathways arising from a balance between protective lifestyle and environmental factors and accumulation of neuropathologies. METHODS As part of the Rush Memory and Aging Project (n = 440), we measured accelerometer‐based actigraphy, cognitive ...
Andrea A. Jones, Alfredo Ramos‐Miguel, Kristina M. Gicas, Vladislav A. Petyuk, Sue E. Leurgans, Philip L. De Jager, Julie A. Schneider, David A. Bennett, William G. Honer, Kaitlin B. Casaletto   +9 more
wiley   +1 more source

Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? [PDF]

, 2015
The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding
Gaetani, Silvana, Passani, Maria B., Provensi, Gustavo, Romano, Adele, Tempesta, Bianca   +4 more
core   +2 more sources

About a snail, a toad and rodents: animal models for adaptation research

Frontiers in Endocrinology, 2010
Neural adaptation mechanisms have many similarities throughout the animal kingdom, enabling to study fundamentals of human adaptation in selected animal models with experimental approaches that are impossible to apply in man.
Eric W Roubos, Bruce G. Jenks, Lu eXu, Miyuki eKuribara, Wim J. J. M. Scheenen, Tamas eKozicz   +5 more
doaj   +1 more source

Multi‐Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk

Small Science, Volume 4, Issue 11, November 2024.
Multi‐organ microphysiological systems (MOMPS) replicate human microphysiology and interorgan crosstalk. The precise fabrication of MOMPS requires various elements, including biomaterials, cell sources, accurate organ crosstalk, biofabrication techniques, and humanized design.
Joeng Ju Kim, Mihyeon Bae, Dong‐Woo Cho   +2 more
wiley   +1 more source

Exposure to extremely low frequency (50 Hz) electromagnetic field changes the survival rate and morphometric characteristics of neurosecretory neurons of the earthworm Eisenia foetida (Oligochaeta) under illumination stress [PDF]

, 2013
An in vivo model was set up to establish the behavioral stress response (rate of survival) and morphometric characteristics of A1 protocerebral neurosecretory neurons (cell size) of Eisenia foetida (Oligochaeta) as a result of the synergetic effect of
Banovački Zorana, Matavulj Milica
core   +1 more source

High signal-to-noise imaging of spontaneous and 5 ns electric pulse-evoked Ca2+ signals in GCaMP6f-expressing adrenal chromaffin cells isolated from transgenic mice.

PLoS ONE, 2023
In studies exploring the potential for nanosecond duration electric pulses to serve as a novel modality for neuromodulation, we found that a 5 ns pulse triggers an immediate rise in [Ca2+]i in isolated bovine adrenal chromaffin cells.
Ciara Viola, Thomas W Gould, Nicole Procacci, Normand Leblanc, Josette Zaklit, Gale L Craviso   +5 more
doaj   +1 more source