Results 41 to 50 of about 7,284 (241)

Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes

open access: yesInternational Journal of Cell Biology, 2014
Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations.
Ashish Thapliyal   +2 more
doaj   +1 more source

Molecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion.

open access: yesPLoS Computational Biology, 2012
Activity regulated neurotransmission shapes the computational properties of a neuron and involves the concerted action of many proteins. Classical, intuitive working models often assign specific proteins to specific steps in such complex cellular ...
L Niels Cornelisse   +5 more
doaj   +1 more source

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

open access: yes, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
Amaral   +51 more
core   +1 more source

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae   +53 more
wiley   +1 more source

Forgetting in C. elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway

open access: yesCell Reports, 2013
The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-
Akitoshi Inoue   +7 more
doaj   +1 more source

mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

open access: yeseLife, 2020
Eukaryotic 5’−3’ mRNA decay plays important roles during development and in response to stress, regulating gene expression post-transcriptionally. In Caenorhabditis elegans, deficiency of DCAP-1/DCP1, the essential co-factor of the major cytoplasmic mRNA
Fivos Borbolis   +10 more
doaj   +1 more source

Targeting ecto‐5′‐nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats

open access: yesThe Journal of Physiology, Volume 604, Issue 1, Page 626-652, 1 January 2026.
Abstract figure legend CD73 promotes carotid body hyperactivity in chronically hypoxic animals. Exposure to chronic hypoxia (CH) (FiO2 of 12% for 10 days) increases the proportion of CD73+TH+ cells in the carotid body and induces basal chemoafferent hyperactivity.
Demitris Nathanael   +4 more
wiley   +1 more source

Physical exercise induces mental flow related to catecholamine levels in noncompetitive, but not competitive conditions in men

open access: yesScientific Reports, 2023
The study aimed to reveal physical exercise conditions and catecholamine response-dependent differences while an individual experiences a flow state (FS) following noncompetitive and competitive running drills.
István Karsai   +8 more
doaj   +1 more source

Dysfunctional Autophagy and Endolysosomal System in Neurodegenerative Diseases: Relevance and Therapeutic Options

open access: yesFrontiers in Cellular Neuroscience, 2020
Autophagy and endolysosomal trafficking are crucial in neuronal development, function and survival. These processes ensure efficient removal of misfolded aggregation-prone proteins and damaged organelles, such as dysfunctional mitochondria, thus allowing
Silvia Giovedì   +9 more
doaj   +1 more source

Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2. [PDF]

open access: yesPLoS Genetics, 2009
It is generally accepted that neuroendocrine cells regulate dense core vesicle (DCV) biogenesis and cargo packaging in response to secretory demands, although the molecular mechanisms of this process are poorly understood.
Tao Cai   +6 more
doaj   +1 more source

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