Results 51 to 60 of about 46,863 (279)
The FEBS Journal, Volume 293, Issue 9, Page 2673-2691, May 2026.Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova +5 more
wiley +1 more source
H3K27me3‐Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion
Plant Biotechnology Journal, Volume 24, Issue 5, Page 2843-2857, May 2026.ABSTRACT Histone H3 lysine 27 trimethylation (H3K27me3) is essential for fungal pathogenicity, yet its contribution to pathogen–host interactions remains incompletely understood. Here, we profiled H3K27me3 dynamics in Fusarium graminearum during infection and identified 132 H3K27me3‐marked genes (FgHMGs).
Xiaozhen Zhao +17 more
wiley +1 more source
A crucial role of the mitochondrial protein import receptor MOM19 for the biogenesis of mitochondria [PDF]
, 1994 The novel genetic method of "sheltered RIP" (repeat induced point mutation) was used to generate a Neurospora crassa mutant in which MOM19, a component of the protein import machinery of the mitochondrial outer membrane, can be depleted.
Harkness, Troy A. A. +4 more
core +8 more sources
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, Volume 13, Issue 23, 23 April 2026.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
MNase Digestion for Nucleosome Mapping in Neurospora
Bio-Protocol, 2016 Digestion of chromatin by micrococcal nuclease MNase followed by high throughput sequencing allows us to determine the location and occupancy of nucleosomes on the genome. Here in this protocol we have described optimized conditions of MNase digestion of
Cigdem Sancar +2 more
doaj +1 more source
Application of Neurospora crassa in the Treatment of Waste [PDF]
, 2014 The nutrient requirements of the fast growing filamentous fungi Neurospora crassa to convert animal waste into an edible product containing high amounts of protein were assessed by selectively excluding nutrients from supplemental solutions of Vogel ...
Przybyla, Matthew, Wunderlich, John
core +1 more source
Biogenesis of mitochondrial porin [PDF]
, 1990 We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann +74 more
core +1 more source
mLife, Volume 5, Issue 2, Page 239-253, April 2026.Abstract Histone modifications and chromatin‐binding proteins play crucial roles in regulating gene expression in eukaryotes, with significant implications for fungal pathogenicity and development. However, profiling these modifications or proteins across the genome in fungi remains challenging due to the technical limitations of the traditional ...
Haiting Wang +11 more
wiley +1 more source
From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family
Protein Science, Volume 35, Issue 4, April 2026.Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer +2 more
wiley +1 more source
G Protein α Subunit Genes Control Growth, Development, and Pathogenicity of Magnaporthe grisea
Molecular Plant-Microbe Interactions, 1997 Three G protein α subunit genes have been cloned and characterized from Magnaporthe grisea: magA is very similar to CPG-2 of Cryphonectria parasitica; magB is virtually identical to CPG-1 of Cryphonectria parasitica, to gna1 of Neurospora crassa, and to ...
Shaohua Liu, Ralph A. Dean
doaj +1 more source