Results 221 to 230 of about 12,549 (250)
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Dehydroepiandrosterone – a neurosteroid
European Journal of Clinical Investigation, 2000Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells.
Friess, E. +3 more
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Neurosteroids and Epileptogenesis
Journal of Neuroendocrinology, 2013Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures occur. This concept has been recently re‐evaluated to include exacerbation of clinically‐manifested epilepsy. Thus, in patients affected by pharmacoresistant seizures, the progression toward a worse condition may be viewed as the result of a durable ...
BIAGINI, Giuseppe +6 more
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2001
In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary +2 more
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In this chapter, we review techniques used for the analysis of neurosteroids and discuss the advantages and disadvantages of each method. Because radioimmunoassay (RIA) procedures are well known, we focus more on the relatively recent mass spectrometric methods used for analyzing neurosteroids and their sulfates.
A A, Alomary +2 more
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Neurosteroids and status epilepticus
Current Opinion in Endocrine and Metabolic Research, 2022Status epilepticus (SE) is a common neurological emergency with considerable associated health-care costs, morbidity, and mortality. In about one-third of cases, SE is refractory towards first-line intravenous benzodiazepines. Allopregnanolone, a neurosteroid that positively modulates synaptic and extrasynaptic γ-aminobutyric acid type A receptors, has
Gol, Mohammad +2 more
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Neurosteroids: recent findings
Brain Research Reviews, 2001The term neurosteroid applies to those steroids that are synthesized in the nervous system, from cholesterol or other blood-borne steroidal precursors, and that accumulate in the nervous system to levels that are at least in part independent from steroidogenic gland secretion.
E, Plassart-Schiess, E E, Baulieu
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Neurochemical Journal, 2021
Abstract—Neurosteroids are steroids that rapidly alter neuronal excitability by interacting with cell surface receptors, mainly the GABA/A receptor complex. Neurosteroids are synthesized both in the central nervous system and in peripheral tissues, from which they enter the brain via systemic blood circulation.
D. A. Zhukov, E. P. Vinogradova
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Abstract—Neurosteroids are steroids that rapidly alter neuronal excitability by interacting with cell surface receptors, mainly the GABA/A receptor complex. Neurosteroids are synthesized both in the central nervous system and in peripheral tissues, from which they enter the brain via systemic blood circulation.
D. A. Zhukov, E. P. Vinogradova
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General and Comparative Endocrinology, 2014
Bargmann-Scharrer's discovery of "neurosecretion" in the first half of the 20th century has since matured into the scientific discipline of neuroendocrinology. Identification of novel neurohormones, such as neuropeptides and neurosteroids, is essential for the progress of neuroendocrinology.
Kazuyoshi, Tsutsui, Shogo, Haraguchi
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Bargmann-Scharrer's discovery of "neurosecretion" in the first half of the 20th century has since matured into the scientific discipline of neuroendocrinology. Identification of novel neurohormones, such as neuropeptides and neurosteroids, is essential for the progress of neuroendocrinology.
Kazuyoshi, Tsutsui, Shogo, Haraguchi
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2001
Neurosteroid production may be a mechanism to counteract the negative effects of stress and return organisms toward homeostasis. Stress induces an increase in neurosteroid production. Neurosteroids affect two of the most widely distributed neurotransmitter and receptor systems in the central nervous system (CNS): gamma-aminobutyric acid (GABA) and ...
S R, Engel, K A, Grant
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Neurosteroid production may be a mechanism to counteract the negative effects of stress and return organisms toward homeostasis. Stress induces an increase in neurosteroid production. Neurosteroids affect two of the most widely distributed neurotransmitter and receptor systems in the central nervous system (CNS): gamma-aminobutyric acid (GABA) and ...
S R, Engel, K A, Grant
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Neurosteroids: Biosynthesis and Function
1994The term "neurosteroids" applies to those steroids that are both synthesized in the nervous system, either de novo from cholesterol or from steroid hormone precursors, and that accumulate in the nervous system to levels at least in part independent of steroidogenic gland secretion rates.
P, Robel, E E, Baulieu
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