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Neurosteroids and Sporadic Alzheimers Disease
Current Alzheimer Research, 2008A reduction of neurosteroids in the brain may initiate sporadic Alzheimer's disease (AD) which comprises >99% of all AD cases. AD research is currently focused on aberrant amyloid precursor protein (APP) processing and the hyper-phosphorylation of tau protein. This is based on early-onset genetic and pathological observations clearly showing that these
Barry, Guy, Ross, Ian L.
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Neurosteroids: Measurement and pathophysiologic relevance
Neurochemistry International, 2008In the last few years, several attempts were made for the setting up of specific methodologies aiming to evaluate steroid contents directly in nervous tissues. The main objective of these attempts was to determine accurately changes intervening in endogenous neuroactive steroid levels during pathological situations.
Roberto Cosimo, Melcangi +1 more
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Neurology, 2007
Neurosteroids are steroids synthesized in glial cells and in some neurons independently of the adrenal glands and gonads.1 Whereas circulating steroids have readily access to the CNS, neurosteroids may act as paracrine signals affecting neuronal function by modulating neurotransmitter-gated ion channels and G-protein-coupled receptors.2,3 Paracrine ...
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Neurosteroids are steroids synthesized in glial cells and in some neurons independently of the adrenal glands and gonads.1 Whereas circulating steroids have readily access to the CNS, neurosteroids may act as paracrine signals affecting neuronal function by modulating neurotransmitter-gated ion channels and G-protein-coupled receptors.2,3 Paracrine ...
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Neurosteroids: Beginning of the story
2001Neurosteroids are synthetisized in the central and the peripheral nervous system, in glial cells, and also in neurons, from cholesterol or steroidal precursors imported from peripheral sources. They include 3 beta-hydroxy-delta 5-compounds, such as pregnenolone (PREG) and dehydroepiandrosterone, their sulfate esters, and compounds known as reduced ...
E E, Baulieu, P, Robel, M, Schumacher
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Clinical implications of circulating neurosteroids
2001Clinical implications of circulating ...
GENAZZANI AR +8 more
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Sheng li ke xue jin zhan [Progress in physiology], 2000
The term "neurosteroids" applies to those steroids that are synthesized in nervous system independent of supply by peripheral endocrine glands. The neurosteroids biosynthetic pathway, the mechanisms of neurosteroids in regulating neuronal activities and the neuromodulatory effects of neurosteroids, particularly the bimodal regulation of GABAA receptors,
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The term "neurosteroids" applies to those steroids that are synthesized in nervous system independent of supply by peripheral endocrine glands. The neurosteroids biosynthetic pathway, the mechanisms of neurosteroids in regulating neuronal activities and the neuromodulatory effects of neurosteroids, particularly the bimodal regulation of GABAA receptors,
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Neurosteroids: Regional Steroidogenesis
2014An enzymatic activity of cytochrome P450 was first identified as a component of adrenal steroidogenesis by Estabrook and his coworkers in 1963. The adrenal glands and gonads synthesize large amounts of steroid hormones and secrete them for systemic circulation. Two decades later, regional steroidogenesis in the brain was well established by Baulieu and
Takeshi Yamazaki, Yasuhiro Ishihara
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