Results 61 to 70 of about 324,229 (240)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Exploring the Causal Relationship and Potential Mediating Mechanisms Between Obesity and Facial Aging: A Two-Sample, Multivariable and Mediation Mendelian Randomization Study

Clinical, Cosmetic and Investigational Dermatology
Jiaqi Lian,1,* Zhiyun Zhang,1,* Wenzhuo Yang,2 Lin Pan,1 Xuyang Pan,1 Ying Shao1 1Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of ...
Lian J, Zhang Z, Yang W, Pan L, Pan X, Shao Y   +5 more
doaj  

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Potential Causal Relationship Between Plasma and Cerebrospinal Fluid Metabolites and Meningioma: Two-Sample Mendelian Randomization Study

Journal of Multidisciplinary Healthcare
Guangyu Du, Daikang Xu, Hai Zhao, Zhiyong Yan, Jianpeng Wang Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, People’s Republic of ChinaCorrespondence: Zhiyong Yan, Department of Neurosurgery, The ...
Du G, Xu D, Zhao H, Yan Z, Wang J
doaj  

The development of the Chinese pediatric neurosurgery for twenty years

Chinese Journal of Contemporary Neurology and Neurosurgery
Since the first Chinese pediatric neurosurgery meeting was convenced in 2002, the pediatric neurosurgery discipline in China has undergone remarkable transformation and growth.
ZHANG Yu-qi, WANG Jun-hua
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

ICAM1-Mediated Endothelial Cells and Macrophage Interactions in Modulating GBM Malignant Transformation

Journal of Inflammation Research
Junlin Li,1,2,* Tingyu Liang,1,* Bo Liang,3,4,* Xiaoman Kang,1 Wenbo Wu,1 Hai Wang,1 Huiyu Yang,1 Yu Wang,1,5 Wenbin Ma1,5 1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and
Li J, Liang T, Liang B, Kang X, Wu W, Wang H, Yang H, Wang Y, Ma W   +8 more
doaj  

Neurosurgery training camp for medical student: experience of the Turkish neurosugery academy and Bursa Uludag University

Frontiers in Surgery
IntroductionTo highlight the importance of hands-on experiences and mentorship in shaping the future workforce of specialized medical professionals via a Neurosurgery Training Camp.MethodsResponses of the questionnaire regarding the Neurosurgery Training
H. Setenay Unal, Mevlut Okan Aydin, Esma Bilgic, Pınar Eser, Zuleyha Alper, M. Ozgur Taskapılıoğlu, M. İlker Kafa, Hasan Kocaeli, Seref Dogan, Selcuk Yılmazlar, Ahmet Bekar, Zeki Sekerci, Kaya Aksoy   +12 more
doaj   +1 more source

Comparison of neurosurgery combined brain radiotherapy versus neurosurgery alone for patients with brain metastases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To summarize the single ⁃ center experience on neurosurgery and neurosurgery combined radiotherapy of brain metastases, and determine factors for prolonged survival time after brain radiotherapy for patients undergoing neurosurgery for brain ...
WANG Yue⁃kun, LIU Lei, CHEN Wan⁃qi, WANG Yu, MA Wen⁃bin   +4 more
doaj  

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source