Treponema pallidum’s neural invasion: from blood-brain barrier breach to immune sabotage [PDF]
Infection and ImmunityNeurosyphilis is an infectious disease of the nervous system caused by Treponema pallidum. With the resurgence of syphilis worldwide, neurosyphilis has become prevalent again, but research on its pathogenesis remains challenging. T.
Han Yu +7 more
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Latent class analysis and machine learning for clinical subtyping prediction and differentiation in suspected neurosyphilis patients [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectiveNeurosyphilis presents significant diagnostic and therapeutic challenges due to its heterogeneous clinical manifestations, absence of a gold-standard diagnostic criterion, and variable treatment responses.
Sirui Wu +6 more
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The relationships of renal function markers with disease activities and neurosyphilis in HIV-negative patients with syphilis [PDF]
European Journal of Medical ResearchObjectives To investigate the associations between renal function markers and disease activities and neurosyphilis in patients with syphilis. Methods A total of 390 HIV-negative syphilis patients were included in the study. Serum blood urea nitrogen (BUN)
Fanghua He +10 more
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Profile of Neurosyphilis Patients Admitted to a Tertiary Care Centre of Nepal: An Observational Study [PDF]
Journal of Nepal Medical AssociationIntroduction: Neurosyphilis is a rare complication of untreated syphilis with limited literature.We aimed to look for demographic characters and clinical presentation of patients admitted with the diagnosis of neurosyphilis.
Uma Giri +3 more
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Neurosyphilis Presenting as Sleep Disorder and Muscle Soreness Complicated With HIV Infection: A Case Report [PDF]
Case Reports in Infectious DiseasesNeurosyphilis is a tertiary syphilis complication or manifestation caused by Treponema pallidum, which invades the central nervous system. Its clinical manifestations are often nonspecific.
Shu-Qi Yang +5 more
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Frontiers in Medicine, 2022 BackgroundIn recent years, the incidence of syphilis has increased year by year. Our study is to explore the risk factors for the development of neurosyphilis in patients who failed syphilis treatment.MethodsA total number of 165 patients with complete ...
Wenying Cui +5 more
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New England Journal of Medicine, 2019 AbstractNeurosyphilis is caused by the bacterium Treponema pallidum subspecies pallidum (T. pallidum). The organism gains entry into the central nervous system (CNS) early (primary syphilis or chancre phase) in the course of infection. While most patients are able to mount an immune response that effectively clears CNS invasion without long-term ...
Hemil, Gonzalez +2 more
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Advances in laboratory diagnostic methods for cerebrospinal fluid testing for neurosyphilis
Frontiers in Public Health, 2022 Neurosyphilis is a chronic infectious disease caused by the invasion of Treponema pallidum into the central nervous system. In recent years, with the increase in the latent syphilis infection rate, the incidence of neurosyphilis has gradually increased ...
Zheng-Xiang Gao +7 more
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Increased interleukin-17 in peripheral blood and cerebrospinal fluid of neurosyphilis patients. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: Treponema pallidum infection evokes vigorous immune responses, resulting in tissue damage. Several studies have demonstrated that IL-17 may be involved in the pathogenesis of syphilis.
Cuini Wang +9 more
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Neurosyphilis in China: A Systematic Review of Cases From 2009–2021
Frontiers in Medicine, 2022 Considered the increased threaten of neurosyphilis in China, a review on cases reported in the literature to describe the clinical epidemiological characteristics of neurosyphilis cases, may be beneficial to the early detection and management strategies ...
Fang-Zhi Du +6 more
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