German guideline on neurosyphilis [PDF]
Neurological Research and PracticeNeurosyphilis is a severe disease which can manifest with various clinical signs. The diagnosis can be challenging. Patients with positive syphilis serology and neurological or psychiatric symptoms should undergo cerebrospinal fluid (CSF) examination ...
Matthias Klein +11 more
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From seropositivity to neurosyphilis: clinical spectrum and diagnostic classification in hospitalized neurology patients: a 16-year retrospective study [PDF]
Frontiers in NeurologyBackgroundNeurosyphilis remains a diagnostic challenge because of its heterogeneous neurological manifestations and the absence of a universally accepted diagnostic gold standard.
Duygu Özkan Yaşargün
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Neurosyphilis in China: A Systematic Review of Cases From 2009–2021
Frontiers in Medicine, 2022 Considered the increased threaten of neurosyphilis in China, a review on cases reported in the literature to describe the clinical epidemiological characteristics of neurosyphilis cases, may be beneficial to the early detection and management strategies ...
Rui-Li Zhang
exaly +3 more sources
German guidelines on the diagnosis and treatment of neurosyphilis
Neurological Research and Practice, 2020 Introduction In view of the importance of neurosyphilis and the difficulties encountered in diagnosing it, the S1 guideline “Neurosyphilis” has been published by the German Society for Neurology (DGN) in accordance with the stipulations of the ...
Matthias Klein +9 more
doaj +2 more sources
Clinical presentation of neurosyphilis – a single-center retrospective data analysis [PDF]
Neurological Research and PracticeBackground As cases of neurosyphilis are rising worldwide – especially in people living with HIV (PLWH) – current data on clinical presentation, diagnostics and management of neurosyphilis in Europe are of high interest.
Susanne Dyckhoff-Shen +5 more
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Treponema pallidum’s neural invasion: from blood-brain barrier breach to immune sabotage [PDF]
Infection and ImmunityNeurosyphilis is an infectious disease of the nervous system caused by Treponema pallidum. With the resurgence of syphilis worldwide, neurosyphilis has become prevalent again, but research on its pathogenesis remains challenging. T.
Han Yu +7 more
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The relationships of renal function markers with disease activities and neurosyphilis in HIV-negative patients with syphilis [PDF]
European Journal of Medical ResearchObjectives To investigate the associations between renal function markers and disease activities and neurosyphilis in patients with syphilis. Methods A total of 390 HIV-negative syphilis patients were included in the study. Serum blood urea nitrogen (BUN)
Fanghua He +10 more
doaj +2 more sources
Frontiers in Medicine, 2022 BackgroundIn recent years, the incidence of syphilis has increased year by year. Our study is to explore the risk factors for the development of neurosyphilis in patients who failed syphilis treatment.MethodsA total number of 165 patients with complete ...
Wenying Cui +5 more
doaj +1 more source
Advances in laboratory diagnostic methods for cerebrospinal fluid testing for neurosyphilis
Frontiers in Public Health, 2022 Neurosyphilis is a chronic infectious disease caused by the invasion of Treponema pallidum into the central nervous system. In recent years, with the increase in the latent syphilis infection rate, the incidence of neurosyphilis has gradually increased ...
Zheng-Xiang Gao +7 more
doaj +1 more source
Increased interleukin-17 in peripheral blood and cerebrospinal fluid of neurosyphilis patients. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND: Treponema pallidum infection evokes vigorous immune responses, resulting in tissue damage. Several studies have demonstrated that IL-17 may be involved in the pathogenesis of syphilis.
Cuini Wang +9 more
doaj +1 more source