Results 211 to 220 of about 149,741 (293)

Methylmercury Pause: Study Suggests Long Latency for Neurotoxicity.

, 2008
Barrett
openalex   +1 more source

Neurotoxic Peptides in the Multicomponent Venom of the Spider Cupiennius Salei Part I. Primary Structure of Neurotoxic Peptides in Relation to their Biological Function

, 2001
Johann Schaller, Lucia Kuhn‐Nentwig, Stefan Schürch, Urs Kämpfer, J.C. Mulier, Wolfgang Nentwig   +5 more
openalex   +2 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Immune Effector Cell-Associated Neurotoxicity Delayed Relapse After Chimeric Antigen Receptor T-Cell Therapy: A Case Report. [PDF]

Neurol Neuroimmunol Neuroinflamm
Favero A, Mohamed S, Battista ML, Cenacchi V, Sartori A, Mazzon G, Bratina A, Tomaselli M, Patriarca F, Zaja F, Manganotti P, Benussi A.   +11 more
europepmc   +1 more source

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Cefepime-Induced Neurotoxicity in an Elderly Patient: A Case Report. [PDF]

Cureus
Herrera M, Caballero CF, Robles BJ, Courville K.   +3 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

A Review of the Role of Neuroimaging in Neurotoxicity Monitoring in Children with Acute Lymphoblastic Leukemia. [PDF]

Med Sci Monit
Rocka A, Walczak ŁJ, Herbut W, Leśniak M, Majka P, Lipniarska J, Lejman M, Zawitkowska J, Woźniak MM.   +8 more
europepmc   +1 more source