Results 261 to 270 of about 242,018 (356)

Case Report: Successful use of emapalumab in adult B-cell acute lymphoblastic leukemia experiencing severe neurotoxicity and hemophagocytic lymphohistiocytosis-like features after CAR-T cell therapy. [PDF]

Front Immunol
Manghisi B, Cotilli G, Fedele M, Perfetti P, Terruzzi E, Verga L, Borin LM, Carrer A, Fumagalli M, Ferrari MB, Moretti A, Rona R, Benini A, Vergnano B, Palumbo G, Zincone A, Maglia O, Scollo C, Steidl C, Iovino L, Balduzzi A, Piazza R, Gambacorti-Passerini C, Parma M, Aroldi A.   +24 more
europepmc   +1 more source

Biomarkers of Neurotoxicity

, 2022
Maciejska, Alicja Magdalena, Skórkowska, Alicja, Jurczyk, Jakub, Pomierny, Bartosz, Budziszewska, Bogusława   +4 more
openaire   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

The interaction between the presynaptic phospholipase neurotoxins beta-bungarotoxin and crotoxin and mixed detergent-phosphatidylcholine micelles. A comparison with non-neurotoxic snake venom phospholipases A2.

, 1987
François Radvanyi, B. Saliou, Cassian Bon, Peter N. Strong   +3 more
openalex   +1 more source

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights

Epileptic Disorders, EarlyView.
Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L. Smith, Ifrah Zawar   +7 more
wiley   +1 more source

Puerarin Attenuates the Cytotoxicity Effects of Bisphenol S in HT22 Cells by Regulating the BDNF/TrkB/CREB Signaling Pathway. [PDF]

Toxics
Qin M, Guo X, Xu N, Su Y, Pan M, Zhang Z, Zeng H.   +6 more
europepmc   +1 more source

Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies. [PDF]

Toxicol Rep
Obafemi BA, Adedara IA, Delgado CP, Obafemi OT, Aschner M, Rocha JBT.   +5 more
europepmc   +1 more source

Compound heterozygosity of a De novo 16q24.1 deletion and missense mutation in COX4I1 leads to developmental regression, intellectual disability, and seizures

Epilepsia Open, EarlyView.
Abstract The COX4I1 is responsible for encoding a crucial component of cytochrome c oxidase, integral to electron transport in the mitochondrial respiratory chain. Mutations in COX4I1 can result in a rare autosomal recessive disorder characterized by growth retardation, slow weight gain, microcephaly, and potentially, hematologic symptoms such as ...
Zhen Liu, Mei He, Xuan Luo, Hu Pan, Xiao Mao, Jinping Su   +5 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

EEG as a predictive biomarker of neurotoxicity in anti-CD19 CAR T-cell therapy. [PDF]

J Neurol
Pondrelli F, Muccioli L, Mason F, Zenesini C, Ferri L, Asioli GM, Rossi S, Rinaldi R, Rondelli F, Nicodemo M, D'Angelo R, Barone V, Sambati L, Pensato U, Zinzani PL, Casadei B, Bonifazi F, Maffini E, Pierucci E, Cortelli P, Tinuper P, Bisulli F, Guarino M.   +22 more
europepmc   +1 more source