Results 291 to 300 of about 242,018 (356)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know? [PDF]

Addiction
Brunt TM, van den Brink W, van Amsterdam J.   +2 more
europepmc   +1 more source

Possible cholinergic involvement in the neurotoxic symptoms evoked by DDT and dieldrin in mice

, 1987
Yasunori Morio, Osamu Yagasaki
openalex   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

radiographic studies of neurotoxic effects of MPTP — MPTP-induced chronic monkey parkinsonism

, 1987
Shozo Kito, Rie Miyoshi, Masami Shimizu, Kosaku Nitta, Hiroaki Matsubayashi, Yasuhiro Yamamura   +5 more
openalex   +1 more source

Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

Food Frontiers, EarlyView.
Organ‐on‐chips offer a promising tool for evaluating food and feed safety. Organ‐on‐chips also present a scientifically robust and ethical alternative to animal studies. ABSTRACT The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, recognizing that the health of each is interdependent and influenced by ...
Manuela Cassotta, Maria Elexpuru‐Zabaleta, Sandra Sumalla Cano, Yasmany Armas Diaz, Francesca Giampieri, Zou Xiaobo, Di Zhang, Giuseppe Grosso, Maurizio Battino   +8 more
wiley   +1 more source

CAR-T Cells for the Treatment of Central Nervous System Tumours: Known and Emerging Neurotoxicities. [PDF]

Brain Sci
Palazzo L, Pieri V, Berzero G, Filippi M.   +3 more
europepmc   +1 more source

Effects of methyl isobutyl ketone on methyl n-butyl ketone neurotoxicity in rats.

, 1988
Megumi Nagano, Koichi Harada, Junichi Misumi, Sigeru Nomura   +3 more
openalex   +2 more sources

Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment

Food Frontiers, EarlyView.
Natural small molecules through nanocarriers for cancer treatment ABSTRACT Cancer is a formidable adversary, accounting for the second highest number of fatalities worldwide. A multitude of studies have indicated that naturally sourced small‐molecule compounds, owing to their low toxicity and multi‐target capabilities, significantly aid in the fight ...
Fangting Ye, Shaojie Zheng, Shuo Shan, Jiaer Cai, Yufan Liu, Weichao Chen, Xinxin He, Chao Zhao   +7 more
wiley   +1 more source

The Role of Autophagy in Copper-Induced Apoptosis and Developmental Neurotoxicity in SH-SY5Y Cells. [PDF]

Toxics
Lu L, Zhang Y, Shi W, Zhou Q, Lai Z, Pu Y, Yin L.   +6 more
europepmc   +1 more source