Results 121 to 130 of about 189,557 (259)

Food Safety Management and Mycotoxins Nexus: A Systematic Review of Mycotoxins Toxicity, Detoxification, Nutritional Impacts, and Economic Importance

Food Safety and Health, EarlyView.
The graphical abstract illustrates the interconnected relationship between food safety management, mycotoxin toxicity, and detoxification strategies, highlighting how preventive measures across the food chain can minimize mycotoxin contamination and reduce adverse health effects in humans/animals.
Chinaza Godswill Awuchi
wiley   +1 more source

Neurological implications of chimeric antigen receptor-T cell therapy

BMJ Neurology Open
Chimeric antigen receptor (CAR)-T cell therapies have transformed the management of relapsed or refractory haematological malignancies and are now being adapted for severe B-cell mediated autoimmune disease, including neuroimmunological disorders.
Tomas Kalincik, Mastura Monif, Izanne Roos, Jennifer Massey, Cassie Nesbitt, Arian Lasocki, Anneke van der Walt, Mark Dowling, Justin Garber, Valeriya Kuznetsova, Simon J Harrison, Mary Ann Anderson, Constantine S Tam, Daniel G Raffoul, Matthias Mulazzani, Irene Ruderman   +15 more
doaj   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Expression and role of HSPA5 in environmental toxin-induced neurological disorders

Frontiers in Molecular Neuroscience
HSPA5 is a member of the HSP70 family of heat shock proteins (HSPs) and functions as a chaperone protein within the endoplasmic reticulum (ER). It plays a role in maintaining ER homeostasis, assists in correct protein folding, and triggers the unfolded ...
Yurong Wang, Yang Lv, Ruidong Zhao, Xin Guo, Jing Gao, Tong Wang, Dongmei Yao, Xin Li, Bingchun Liu, Jianlong Yuan   +9 more
doaj   +1 more source

Neurotoxicity and Mechanism in Zebrafish Embryo Induced by Tetrabromobisphenol A bis (2-Hydroxyethyl) Ether (TBBPA-DHEE) Exposure

Tetrabromobisphenol A bis (2-hydroxyethyl) ether (TBBPA-DHEE), a derivative of TBBPA, has been frequently detected in the environment. In this study, the median lethal concentration (LC50) of TBBPA-DHEE at 96 h post-fertilization (hpf) was 1.573 mg/L ...
Xia Xu, Liguo Guo, Yiwen Luo, Yingang Xue, Ying Han, Xinyu Zhang, Haohao Sun, Hui Chen, Guixiang Ji   +8 more
core   +1 more source

Kisspeptin prevention of Amyloid-β Peptide neurotoxicity in vitro

, 2012
Alzheimer’s disease (AD) onset is associated with changes in hypothalamic-pituitary–gonadal (HPG) function. The 54 amino acid kisspeptin (KP) peptide regulates the HPG axis and alters antioxidant enzyme expression.
Chilumuri, Amrutha, Nercessian, A.N., Ashioti, Maria, Nercessian, Amanda N., Rocha-Ferreira, Eridan, Milton, N.G.N., Milton, Nathaniel G. N., Chilumuri, A., Rocha-Ferreira, E., Ashioti, M.   +9 more
core   +1 more source

Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health

Ibrain, EarlyView.
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi, Aarzoo, Chakkaravarthi Saravanan, Heera Ram, Bhim Pratap Singh   +4 more
wiley   +1 more source

Evaluation of warning strategies for paraneoplastic neurological syndromes associated with PD-1/PD-L1 inhibitors

Frontiers in Immunology
BackgroundThe suppressive effects of immune checkpoint inhibitors (ICIs) on anti-tumor immunity have been well documented. However, ICIs can enhance immune responses and trigger autoimmune-related diseases by blocking PD-1 or PD-L1.
Zhuangzhuang Ren, Yudan Liu, Jianguo Liu, Xiaokun Qi, Feng Qiu, Chenjing Sun   +5 more
doaj   +1 more source

Assessment of Cancer‐Related Cognitive Impairments Across Anti‐Cancer Therapies in a Predominantly Breast Cancer Cohort

International Journal of Cancer, EarlyView.
ABSTRACT Cancer survivors frequently experience cancer‐related cognitive impairment (CRCI), but the contributions of different anti‐cancer therapies remain unclear. Patients with breast or gynaecological cancer were recruited before any anti‐cancer treatment.
Qiqi Lei, Martina E. Schmidt, Philipp Zimmer, Patric Meyer, Andreas Schneeweiss, Karen Steindorf   +5 more
wiley   +1 more source

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

iMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson, Liam Scott, Irene Leung, Ferenc Sallo, Catherine Egan, Tunde Peto, The MacTel Consortium, Melanie Bahlo, Martin Friedlander, Simone Tzaridis, Lea Scheppke, Roberto Bonelli   +11 more
wiley   +1 more source