Results 181 to 190 of about 189,557 (259)

Persistent Chemotherapy-Induced Peripheral Neuropathy as a Chronic Cancer Pain Syndrome: Mechanisms, Therapeutic Limitations, and Future Directions. [PDF]

Cancers (Basel)
Firestone RA, Morrison J.
europepmc   +1 more source

Real‐world outcomes of ide‐cel and cilta‐cel in relapsed/refractory multiple myeloma: A nationwide, retrospective analysis in Austria

British Journal of Haematology, EarlyView.
Summary B‐cell maturation antigen‐directed chimeric antigen receptor (CAR) T cells have revolutionized the treatment of relapsed/refractory multiple myeloma. However, no randomized head‐to‐head comparison of idecabtagene vicleucel (ide‐cel) and ciltacabtagene autoleucel (cilta‐cel) is available, and real‐world data suggest differences in efficacy and ...
Irene Strassl, Alexander Nikoloudis, Lina Zoe Ruesing, Thomas Melchardt, Michael Leisch, Eduard Schulz, Annkristin Heine, Peter Neumeister, Normann Steiner, Dominik Wolf, Wolfgang Willenbacher, Petra Pichler‐Izmir, Theresa Lentner, Johannes Clausen, Veronika Buxhofer‐Ausch, Sigrid Machherndl‐Spandl, Olga Saini, Dagmar Wipplinger, Holger Rumpold, Nina Worel, Werner Rabitsch, Axel Schulenburg, Hermine Agis, Maria‐Theresa Krauth   +23 more
wiley   +1 more source

Brain magnetic resonance imaging markers of vigabatrin-associated neurotoxicity during hyperpyrexia-triggered focal status epilepticus: cause or coincidence? [PDF]

Pediatr Radiol
Errichiello G, Tortora M, Cristofano A, Russo C, Varone A.   +4 more
europepmc   +1 more source

Dynamic risk stratification using early CAR‐T expansion in R/R LBCL treated with axicabtagene ciloleucel

British Journal of Haematology, EarlyView.
Higher chimeric antigen receptor‐T expansion at day 7 is associated with improved progression‐free survival but also increased toxicity in axi‐cel treated patients with R/R large B‐cell lymphoma, independent of other baseline patient and disease characteristics.
Brydon Panozzo, Samuel Robinson, Adrian G. Minson, Jian Li, Kylie Baldwin, Hamish W. Scott, Jane Oliaro, Aaron J. N. Wong, Samantha van der Linde, Nicole L. O'Leary, Philip A. Thompson, John F. Seymour, Mary Ann Anderson, Constantine S. Tam, Simon J. Harrison, Michael J. Dickinson, David A. Westerman, Mark R. Dowling   +17 more
wiley   +1 more source

Delayed fatal neurotoxicity in post CAR-T cell therapy for multiple myeloma, a case report. [PDF]

Leuk Res Rep
Khoudari H, Shoaib A, Nashatizadeh M, Ahmed N, Lutfi F, Mushtaq M, Shune L, Singh A, Abhyankar S, McGuirk J, Abdelhakim H.   +10 more
europepmc   +1 more source

Non-ICANS neurotoxicities CD19-directed CAR T-cell therapy and the emergence of movement and neurocognitive treatment-emergent adverse events: a case report. [PDF]

Front Immunol
Schroeder T, Chitadze G, Dargvainiene J, Martens T, Gebauer N, Frimmel J, Brüggemann M, Valerius T, Schub N, Baldus CD, Pott C, Leypoldt F, Stürner K, Stölzel F.   +13 more
europepmc   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Severe Immune-Related Neurological Adverse Events Associated With Immune Checkpoint Inhibitor Treatment: A Retrospective Single-Center Study. [PDF]

Eur J Neurol
Grisold A, Starzer AM, Silvaieh S, Krenn M, Aretin MB, Schmidinger M, Ressler JM, Polterauer S, Berger T, Preusser M, Berghoff AS.   +10 more
europepmc   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Deciphering the Formulation-Dependent Neurotoxicity of Irinotecan: An Integrated Pharmacovigilance and Mechanistic Study. [PDF]

J Biochem Mol Toxicol
Shen C, Ma W, Lu J, Tang Y, Cao W.
europepmc   +1 more source