Results 101 to 110 of about 191,466 (342)
Angewandte Chemie, EarlyView.Pilze haben zweimal unabhängig gelernt, Psilocybin, den ikonischen Naturstoff der Zauberpilze, herzustellen. Dieser Artikel stellt die Enzyme des zweiten Biosyntheseweges vor, der in einem Risspilz gefunden wurde. Verblüffenderweise stimmen die beiden Wege in keiner Reaktion überein.
Tim Schäfer +3 more
wiley +1 more source
Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]
, 2014 The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
*EQUAL CONTRIBUTION +12 more
core +1 more source
Frontiers in PharmacologyThe synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi +2 more
doaj +1 more source
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]
, 2015 Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P. +2 more
core +1 more source
Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms
Angewandte Chemie International Edition, EarlyView.Mushrooms have learned twice independently how to make the iconic magic mushroom natural product psilocybin. This article introduces the enzymes of the second pathway, found in a fiber cap mushroom. Curiously, the two pathways do not share any reaction, nor do the enzymes show a close relationship, but both pathways proceed via 4‐hydroxytryptamine as a
Tim Schäfer +3 more
wiley +1 more source
Iron Deficiency in Infancy and Its Impact on Motor and Mental Development [PDF]
, 2020 Iron plays a large role in nerve myelination, dopamine neurotransmission, and neuronal metabolism. The purpose of this literary review was to investigate the connection between iron deficiency and motor and cognitive development.
Baker, Emma
core +1 more source
Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
core +2 more sources
Watching neurotransmission in vitro [PDF]
Nature Methods, 2011 A well-established approach to study a cellular process is to reconstitute the system in vitro. Researchers in several laboratories, including that of Axel Brunger at Stanford University, have been using this strategy to understand neurotransmitter release.
openaire +3 more sources
Resistive communications based on neuristors
, 2017 Memristors are passive elements that allow us to store information using a single element per bit. However, this is not the only utility of the memristor.
Pizzo, David Alejandro Trejo
core +1 more source
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]
, 2017 Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y +12 more
core +1 more source