Results 101 to 110 of about 218,364 (416)

Glutamatergic Neurotransmission in Alcoholism

Journal of Biomedical Science, 1998
Substance abuse and dependence is the most common psychiatric problem. Alcohol is the most commonly abused substance and most people who abuse other substance(s) abuse alcohol at the same time ...
openaire   +3 more sources

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

Advanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng‐Jiang Zhu   +4 more
wiley   +1 more source

In VivoAdenovirus-Mediated Gene Transfer for Parkinson's Disease

Neurobiology of Disease, 1997
Gene therapy is a potentially powerful approach to the treatment of neurological diseases. Neurotransmitter synthesizing enzymes and neurotrophic factors inhibiting neurodegenerative processes provide the basis for current development of gene therapy ...
Philippe Horellou, Alicia Bilang-Bleuel, Jacques Mallet   +2 more
doaj  

Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex

Frontiers in Pharmacology
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Simon Bossi, Hervé Daniel, Heather McLean   +2 more
doaj   +1 more source

Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR

Frontiers in Molecular Neuroscience, 2013
A wide range of light-activated molecules (photoswitches and phototriggers) have been used to the study of computational properties of an isolated neuron by acting pre and postsynaptically.
Mercè eIzquierdo-Serra, Dirk eTrauner, Artur eLlobet, Pau eGorostiza, Pau eGorostiza, Pau eGorostiza   +5 more
doaj   +1 more source

In Situ Electrically Resettable Field‐Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection

Advanced Science, EarlyView.
The research team integrated a potentiometrically controlled pH electrode with carbon nanotube (CNT) field‐effect transistor (FET) biosensors on a single chip using compatible processes. By employing zonal modification and optimized pH‐sensitive probes, they achieved simultaneous quadruple‐target detection and tenfold reusability under physiological ...
Bo Xiao, Tingxian Li, Xianmao Cao, Yang Zhang, Jianping He, Mengmeng Xiao, Zhiyong Zhang   +6 more
wiley   +1 more source

Endocytic proteins drive vesicle growth via instability in high membrane tension environment [PDF]

, 2015
Clathrin-mediated endocytosis (CME) is a key pathway for transporting cargo into cells via membrane vesicles. It plays an integral role in nutrient import, signal transduction, neurotransmission and cellular entry of pathogens and drug-carrying nanoparticles.
arxiv   +1 more source

Quantifying constraints determining independent activation on NMDA receptors mediated currents from evoked and spontaneous synaptic transmission at an individual synapse [PDF]

arXiv, 2022
A synapse acts on neural transmission through a chemical process called synapses fusion between pre-synaptic and post-synaptic terminals. Presynaptic terminals release neurotransmitters either in response to action potential or spontaneously independent of presynaptic activity.
arxiv  

Glassy Carbon Microelectrode Arrays Enable Voltage-Peak Separated Simultaneous Detection of Dopamine and Serotonin Using Fast Scan Cyclic Voltammetry [PDF]

, 2020
Progress in real-time, simultaneous in vivo detection of multiple neurotransmitters will help accelerate advances in neuroscience research. The need for development of probes capable of stable electrochemical detection of rapid neurotransmitter fluctuations with high sensitivity and selectivity and sub-second temporal resolution has, therefore, become ...
arxiv   +1 more source

m6A Demethylase FTO Regulates Dopaminergic Neurotransmission Deficits Caused by Arsenite

Toxicological Sciences, 2018
Arsenite exposure is known to increase the risk of neurological disorders via alteration of dopamine content, but the detailed molecular mechanisms remain largely unknown. In this study, using both dopaminergic neurons of the PC-12 cell line and C57BL/6J
Lulu Bai, Qianghu Tang, Zhen Zou, P. Meng, Bai-jie Tu, yinyin xia, Shuqun Cheng, Lina Zhang, Kai Yang, Shaoyu Mu, Xuefeng Wang, Xia Qin, Bo Lv, Xianqing Cao, Qizhong Qin, Xuejun Jiang, Chengzhi Chen   +16 more
semanticscholar   +1 more source