Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3 [PDF]
, 2016 The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking
A Amphoux +51 more
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A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission [PDF]
, 2020 Carlos Lafourcade +8 more
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Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome
Frontiers in Neuroscience, 2018 The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic system, a presynaptic hyperdopaminergic state, seem to be involved in PLMS, while ...
S. Ferré +12 more
semanticscholar +1 more source
Subicular Astrocytes Govern Seizure‐Impaired Fear Memory
Advanced Science, EarlyView.Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao +15 more
wiley +1 more source
Field effects in the CNS play functional roles
Frontiers in Neural Circuits, 2010 An endogenous electrical field effect, i.e. ephaptic transmission, occurs when an electric field associated with activity occurring in one neuron polarizes the membrane of another neuron.
Shennan A Weiss, Donald S Faber
doaj +1 more source
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]
, 2015 Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P. +2 more
core +1 more source
Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
npj Parkinson's Disease, 2016 In view of its ability to explain the most frequent motor symptoms of Parkinson’s Disease (PD), degeneration of dopaminergic neurons has been considered one of the disease’s main pathophysiological features.
S. Pérez-Lloret, F. Barrantes
semanticscholar +1 more source
Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention
Advanced Science, EarlyView.This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi +14 more
wiley +1 more source
The Nucleus of the Solitary Tract and the coordination of respiratory and sympathetic activities
Frontiers in Physiology, 2014 It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial pressure levels. Sympathetic oscillations coupled to the respiratory activity have been suggested as an important homeostatic mechanism optimizing tissue ...
Daniel B. Zoccal +4 more
doaj +1 more source
eLife, 2020 We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (RIMS1, CHD8, CHD2, WDFY3, ASH1L) causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila.
Özgür Genç +6 more
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