Results 111 to 120 of about 224,377 (390)

The Nucleus of the Solitary Tract and the coordination of respiratory and sympathetic activities

Frontiers in Physiology, 2014
It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial pressure levels. Sympathetic oscillations coupled to the respiratory activity have been suggested as an important homeostatic mechanism optimizing tissue ...
Daniel B. Zoccal, Werner I. Furuya, Mirian eBassi, Débora S. A. Colombari, Eduardo eColombari   +4 more
doaj   +1 more source

Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

eLife, 2020
We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (RIMS1, CHD8, CHD2, WDFY3, ASH1L) causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila.
Özgür Genç, Joon-Yong An, Richard D Fetter, Yelena Kulik, Giulia Zunino, Stephan J Sanders, Graeme W Davis   +6 more
doaj   +1 more source

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

, 2019
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored.
Bansal, V., Bonn, S., Fornasiero, E., Fritsch, E., Gomes, L., Gärtner, A., Keihani, S., Klüver, V., Kügler, S., Mandad, S., Rahman, R., Rizzoli, S., Urlaub, H., Wren, J.   +13 more
core   +1 more source

Substance abuse and neurotransmission

, 2022
The number of people who suffer from a substance abuse disorder has continued to rise over the last decade; particularly, the number of drug-related overdose deaths has sharply increased during the COVID-19 pandemic. Converging lines of clinical observations, supported by imaging and neuropsychological performance testing, have demonstrated that ...
Davis, Sarah, Zhu, Jun
openaire   +2 more sources

Anxiety disorders and GABA neurotransmission: a disturbance of modulation

Neuropsychiatric Disease and Treatment, 2015
Lines of evidence coming from many branches of neuroscience indicate that anxiety disorders arise from a dysfunction in the modulation of brain circuits which regulate emotional responses to potentially threatening stimuli.
P. Nuss
semanticscholar   +1 more source

Multifunctional NIR‐Triggered Nanozyme‐Based Microneedles for Synergistic Eradication of MRSA and Enhanced Wound Healing

Advanced Science, EarlyView.
The novel microneedle patches (MN@CTB) are fabricated by integrating CTB nanozymes into HAMA and PVA solution based on a photo‐crosslinking reaction. The MN@CTB microneedle patches present an excellent photothermal effect and NIR‐stimulated release of NO, which is advantageous for the elimination of MRS.
Wei Qian, Ruixi Li, Xiyan Zheng, Yingliang Li, Haiwei Xiong, Ye Zhang, Dengliang Lei, Qingfeng Shi, Yufeng Xie, Yiting Zhou, Bailong Tao, Kuai Yu, Aiping Le, Boxuan Zhou   +13 more
wiley   +1 more source

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2015
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P., Kantak, Kathleen M., Somkuwar, Sucharita S.   +2 more
core   +4 more sources

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Ionic‐Electronic Coupling Modulation Induced by Nanofibrous Phase Separation for Synaptic Organic Electrochemical Transistors

Aggregate, EarlyView.
Nanofibrous phase separationengineered polymer blends enable ionic‐electronic coupling modulation in organic electrochemical transistors. The resulting synaptic devices exhibit multiscale plasticity, stochastic weight updating, and robust classification performance, offering a scalable material strategy toward hardware‐based neuromorphic computing ...
Canghao Xu, Lin Gao, Yujie Peng, Changjian Liu, Ding Zheng, Junsheng Yu   +5 more
wiley   +1 more source

Astrocytic GABA transporter activity modulates excitatory neurotransmission

Nature Communications, 2016
Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters.
Kim Boddum, Thomas P. Jensen, Vincent Magloire, U. Kristiansen, D. Rusakov, I. Pavlov, M. Walker   +6 more
semanticscholar   +1 more source