Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]
, 2015 Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa +6 more
core +2 more sources
Mammalian Tolerance to Amino Acid Heterochirality
ChemBioChem, Accepted Article.Organisms use amino acids predominantly in l‐configuration. On the other hand, a series of studies show that a variety of d‐amino acids also occur in mammals and amino acid homochirality is not complete. Mammals de novo synthesize most amino acids with l‐configuration, but serine and aspartate are converted from l‐ to d‐configuration by endogenous ...
Jumpei Sasabe +4 more
wiley +1 more source
A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity
eLife, 2018 Presynaptic homeostatic plasticity stabilizes information transfer at synaptic connections in organisms ranging from insect to human. By analogy with principles of engineering and control theory, the molecular implementation of PHP is thought to require ...
Anna G Hauswirth +5 more
doaj +1 more source
Computational Astrocyence: Astrocytes encode inhibitory activity into the frequency and spatial extent of their calcium elevations [PDF]
arXiv, 2019 Deciphering the complex interactions between neurotransmission and astrocytic $Ca^{2+}$ elevations is a target promising a comprehensive understanding of brain function. While the astrocytic response to excitatory synaptic activity has been extensively studied, how inhibitory activity results to intracellular $Ca^{2+}$ waves remains elusive.
arxiv
Normal spatial learning and improved spatial working memory in mice (mus musculus) lacking dopamine d4 receptors [PDF]
, 2001 Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor ...
Avale, Maria Elena +3 more
core +1 more source
ChemMedChem, Accepted Article.We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi +18 more
wiley +1 more source
Imaging neuropeptide release at synapses with a genetically engineered reporter
eLife, 2019 Research on neuropeptide function has advanced rapidly, yet there is still no spatio-temporally resolved method to measure the release of neuropeptides in vivo.
Keke Ding +7 more
doaj +1 more source
Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?
Ageing Research Reviews, 2022 Xiaohuan Xia +4 more
semanticscholar +1 more source
Astrocytic GABA transporter activity modulates excitatory neurotransmission
Nature Communications, 2016 Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters.
Kim Boddum +6 more
semanticscholar +1 more source
Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]
, 2019 The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M. +11 more
core +1 more source