Results 151 to 160 of about 224,377 (390)

Reaction of N‐Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo

ChemMedChem, EarlyView.
Nitric oxide induces decomposition of electron‐deficient aminoferrocene drugs 4 with formation of oxime 7, which is derived from the upper cyclopentadienyl ligand. Drugs 4 are not responsive to hydrogen peroxide. Based on the latter reaction, the fluorogenic probes are developed for detecting NO in cells and inflammation in vivo.
Roman Selin, Hülya Gizem Özkan, Galyna Bila, Rostyslav Bilyy, Andriy Mokhir   +4 more
wiley   +1 more source

Synaptic GABAergic transmission in the central amygdala (CeA) of rats depends on slice preparation and recording conditions

Physiological Reports, 2019
The central nucleus of the amygdala (CeA) is a primarily GABAergic brain region implicated in stress and addictive disorders. Using in vitro slice electrophysiology, many studies measure GABAergic neurotransmission to evaluate the impact of experimental ...
Elizabeth M. Avegno, Jason W. Middleton, Nicholas W. Gilpin   +2 more
doaj   +1 more source

Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans

eLife, 2015
Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior?
Sarah G Leinwand, Claire J Yang, Daphne Bazopoulou, Nikos Chronis, Jagan Srinivasan, Sreekanth H Chalasani   +5 more
doaj   +1 more source

Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission [PDF]

, 1971
Leslie L. Iversen
openalex   +1 more source

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Neurotransmission [PDF]

, 1973
J. H. BURN
openalex   +1 more source

Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals ( 
Joan M. Jasien, Jacques A. Stout, Mohamad A. Mikati, Robert J. Anderson, Brittany G. Nave, Herbert E. Fuchs, Brian Smith, Alexandra Badea, Jeffrey N. Browndyke   +8 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats [PDF]

, 1988
Terry E. Robinson, Phillip A. Jurson, Julie A. Bennett, Kris M. Bentgen   +3 more
openalex   +1 more source

How Sodium Dodecyl Sulfate Micelles Affect the Coordination and Peroxidase‐Like Activity of the Hemin–Aβ16 Complex

ChemPlusChem, EarlyView.
The interaction between iron‐heme and amyloid‐β (Aβ) peptides can be strongly influenced by the cellular compartment. The presence of sodium dodecyl sulfate as a lipid‐mimicking system shows a protective role of the membrane by hindering both the formation of the heme–Aβ complex and the peroxidase‐like activity, reducing the accessibility of the lipid ...
Chiara Bacchella, Simone Novellini, Elisa Miotto, Stefania Nicolis, Enrico Monzani, Simone Dell’Acqua   +5 more
wiley   +1 more source