Results 151 to 160 of about 218,364 (416)

The biopsychosocial context of ADHD. [PDF]

, 2005
attention-deficit/hyperactivity disorder (adhd) represents adaptation to defective neurotransmission – an adaptation seldom with benefit. the resulting behavioural style not only increases vulnerability to adverse experiences, but also creates a context ...
Sandberg, S
core   +1 more source

Watching neurotransmission in vitro [PDF]

Nature Methods, 2011
A well-established approach to study a cellular process is to reconstitute the system in vitro. Researchers in several laboratories, including that of Axel Brunger at Stanford University, have been using this strategy to understand neurotransmitter release.
openaire   +3 more sources

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights

Epileptic Disorders, EarlyView.
Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L. Smith, Ifrah Zawar   +7 more
wiley   +1 more source

The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission

Nature Communications, 2017
Dopamine neurotransmission is highly dysregulated by the psychostimulant methamphetamine, a substrate for the dopamine transporter (DAT). Through interactions with DAT, methamphetamine increases extracellular dopamine levels in the brain, leading to its ...
Danielle O Sambo, Min Lin, A. Owens, J. Lebowitz, B. Richardson, Darin A. Jagnarine, Madhur Shetty, Meghan Rodriquez, Taiwo Alonge, Mishaal Ali, J. Katz, Long Yan, M. Febo, L. Henry, Adriaan W. Bruijnzeel, L. Daws, Habibeh Khoshbouei   +16 more
semanticscholar   +1 more source

Structural and functional dynamics of Excitatory Amino Acid Transporters (EAAT)

AIMS Molecular Science, 2014
Glutamate transporters control the glutamate homeostasis in the central nervous system, and, thus, are not only crucial for physiological excitatory synaptic signaling, but also for the prevention of a large number of neurodegenerative diseases that are ...
Thomas Rauen, Rose Tanui, Christof Grewer   +2 more
doaj   +1 more source

Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury.

Journal of Neurotrauma, 2017
Traumatic brain injury (TBI) is a leading cause of death and disability in people younger than 45 and is a significant public health concern. In addition to primary mechanical damage to cells and tissue, TBI involves additional molecular mechanisms of ...
Christopher R. Dorsett, J. McGuire, Erica A. K. DePasquale, A. Gardner, Candace L. Floyd, R. Mccullumsmith   +5 more
semanticscholar   +1 more source

Effects of lack of microRNA-34 on the neural circuitry underlying the stress response and anxiety [PDF]

, 2016
Stress-related psychiatric disorders, including anxiety, are complex diseases that have genetic, and environmental causes. Stressful experiences increase the release of prefrontal amygdala neurotransmitters, a response that is relevant to cognitive ...
ANDOLINA, DIEGO, Bisicchia, Elisa, CESTARI, VINCENZO, Concepcion, Carla, D'ALESSANDRO, Francesca, DI SEGNI, MATTEO, PUGLISI ALLEGRA, Stefano, Ventura, Andrea, VENTURA, Rossella   +8 more
core   +1 more source

Interpretable multimodal fusion networks reveal mechanisms of brain cognition [PDF]

arXiv, 2020
Multimodal fusion benefits disease diagnosis by providing a more comprehensive perspective. Developing algorithms is challenging due to data heterogeneity and the complex within- and between-modality associations. Deep-network-based data-fusion models have been developed to capture the complex associations and the performance in diagnosis has been ...
arxiv  

Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a condition of neurological emergency, which precipitates various functional and morphological changes in the brain. Due to the risk of drug resistance associated with SE, this study aimed to evaluate a multitargeted approach to treat SE by combining clinically used antiseizure drugs. Methods In this study,
Sana Javaid, Faleh Alqahtani, Abida Parveen, Waseem Ashraf, Zohabia Rehman, Syed Muhammad Muneeb Anjum, Tanveer Ahmad, Imran Imran   +7 more
wiley   +1 more source

Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation [PDF]

, 2018
Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Mennerick, Steven, Shu, Hong-Jin, Sobieski, Courtney, Warikoo, Natasha   +3 more
core   +3 more sources