Results 151 to 160 of about 191,466 (342)

Population Pharmacokinetic and Exposure‐Efficacy Analyses of Valbenazine in Patients with Huntington's Disease: Supporting Dose Selection for Chorea Management

The Journal of Clinical Pharmacology, EarlyView.
Abstract Valbenazine improved chorea in individuals with Huntington's disease compared to placebo in a phase 3, placebo‐controlled study (KINECT‐HD). Population pharmacokinetics (PK) and exposure–response (E–R) analyses focused on understanding the PK characteristics of valbenazine and its active metabolite, [+]‐α‐dihydrotetrabenazine ([+]‐α‐HTBZ), and
Hoa Q. Nguyen, Ryan L. Crass, Sunny Chapel, Han‐Yi Steve Kuan, Gordon Loewen, Satjit Brar   +5 more
wiley   +1 more source

Fatty acid profiles in blood and tissues of parenteral nutrition–fed neonatal piglets using a novel lipid emulsion containing choline

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background For parenteral nutrition (PN)–dependent neonates, soybean oil intravenous lipid emulsions (SO‐ILEs) and mixed emulsions (SO, medium‐chain triglyceride [MCT], olive oil [OO], and fish oil [FO] ILEs) are likely not providing adequate amounts of key fatty acids (FAs) arachidonic acid (AA) and docosahexaenoic acid (DHA) and are devoid ...
Mirielle L. Pauline, Caitlin Huynh, Rohan Persad, Pamela R. Wizzard, Patrick N. Nation, Rajibur Rahman, Benjamin P. Willing, Catherine J. Field, Abdelatif Elouahabi, Thibault Senterre, Paul W. Wales, Justine M. Turner   +11 more
wiley   +1 more source

Inhibitory Effect of Halothane on the Electrophysiological Parameters of Neurotransmission in Rat Cut Diaphragm [PDF]

, 1994
Soo Il Lee, Seong Woo Choo
openalex   +1 more source

Microplastics in Agricultural Soil: Fate, Impacts, and Bioremediation by Earthworms

Journal of Plant Nutrition and Soil Science, EarlyView.
Microplastics enter the soil through various means, including the degradation of plastic film mulch, waste from cosmetics industries and municipalities, and the use of bioplastic seed coatings. These microplastics disrupt soil structure, microbial activity, enzyme function, and plant growth.
Sami ur Rehman, Mudassar Hussain, Federica De Castro, Michele Benedetti, Alessio Aprile, Francesco Paolo Fanizzi   +5 more
wiley   +1 more source

P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders

Medicine Bulletin, EarlyView.
ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley   +1 more source

Dual effect of .GAMMA.-aminobutyric acid (GABA) on neurotransmission in the superior colliculus slices from the guinea pig.

, 1987
Toshio Arakawa, Yasuhiro Okada
openalex   +2 more sources

Electrophysiological Evidence for Impaired Central Pain Modulation in Parkinson's Disease

Movement Disorders, EarlyView.
Our study demonstrates electrophysiological evidence of impaired central pain modulation in Parkinson's disease (PD) patients using laser‐evoked potential habituation and quantitative sensory testing. PD patients exhibited reduced habituation to painful stimuli, independent of reported pain or medication.
Dilara Kersebaum, Josephine Lassen, Julia Forstenpointner, Manon Sendel, Sophie‐Charlotte Fabig, Sonja Nölker, Juliane Sachau, Steffen Paschen, Daniela Berg, Ralf Baron, Philipp Hüllemann   +10 more
wiley   +1 more source

Effects of Atrial Natriuretic Factor on Noradrenergic Neurotransmission In Vivo in the Rat Mesentery

, 1987
William A. Herzer, Gilbert Deray, Edwin K. Jackson   +2 more
openalex   +1 more source

Characterization of nitrergic neurotransmission during short‐and long‐term electrical stimulation of the rabbit anococcygeus muscle [PDF]

, 1995
Lübomir Kasakov, Selim Cellek, Salvador Moncada   +2 more
openalex   +1 more source

Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Visual hallucinations (VHs) are a common feature of Parkinson's disease (PD) believed to arise from disruptions to the functional architecture supporting sensory integration and attentional control. Across synucleinopathies, increased pathological burden in the amygdala and deficits in cholinergic modulation have been linked to VHs.
Anna Ignatavicius, Lachlan Churchill, Jack Anderson, Ajay Konuri, Claire O'Callaghan, Simon J.G. Lewis, Elie Matar   +6 more
wiley   +1 more source