Results 181 to 190 of about 224,377 (390)

Comparison of neurotransmission with nerve trunk and transmural field stimulation in guinea‐pig mesenteric artery. [PDF]

, 1991
Kathleen D. Keef, O. D. Hottenstein, A G Meehan, Todd L. Anthony, David L. Kreulen   +4 more
openalex   +1 more source

Exploring the Multifunctional Agents of Flavonoid‐Rich Beet Leaf Extracts: Insights From Experimental and Computational Studies

Food Safety and Health, EarlyView.
ABSTRACT This study evaluated the multifunctional ability of Beta vulgaris leaves in dual therapy for Alzheimer's disease (AD) and type 2 diabetes (T2D). Flavonoid‐rich extracts of B. vulgaris leaves (FREBVL) were tested for their antidiabetic properties. The inhibition of α‐amylase and α‐glucosidase was assessed. Anti‐cholinesterase activities against
Gideon Ampoma Gyebi, Damilare Emmanuel Rotimi, Moyosoreoluwa Oduba, Ifeoma Nnonyelu, Matthew Iyobhebhe, Musiliyu Ayofe Salawu, Adebola Busola Ojo, Odunayo Anthonia Taiwo, Adesoji Alani Olanrewaju, Abel Kolawole Oyebamiji, Mubarak Alruwaili, Naif H. Ali, Saud A. Alnaaim, Bshra A. Alsfouk, Gaber El‐Saber Batiha, Oluwafemi Adeleke Ojo   +15 more
wiley   +1 more source

Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead

Advanced Genetics, EarlyView.
Optogenetics provides up to millisecond scale, cell type‐specific control of biology using light‐sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins and photoactivated enzymes to allosteric switches, surveys broad applications in neuroscience, molecular and cell biology, cardiology, immunology, and ...
Xiao Duan, Mo Zhu, Shiqiang Gao
wiley   +1 more source

Inhibitory Effect of Halothane on the Electrophysiological Parameters of Neurotransmission in Rat Cut Diaphragm [PDF]

, 1994
Soo Il Lee, Seong Woo Choo
openalex   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

Glia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller, Nadège Zanou, Sylviane Lagarrigue, Tamara Zehnder, Cathy Gouelle, Tania Santoro, Cendrine Repond, Paola Bezzi, Francesca Amati, Anne‐Karine Bouzier‐Sore, Ariane Sharif, Luc Pellerin   +11 more
wiley   +1 more source

Codes between Poles: Linking Transcriptomic Insights into the Neurobiology of Bipolar Disorder

Biology
Bipolar disorder (BPD) is a serious psychiatric condition that is characterized by the frequent shifting of mood patterns, ranging from manic to depressive episodes.
Jon Patrick T. Garcia, Lemmuel L. Tayo
doaj   +1 more source

Effects of Atrial Natriuretic Factor on Noradrenergic Neurotransmission In Vivo in the Rat Mesentery

, 1987
William A. Herzer, Gilbert Deray, Edwin K. Jackson   +2 more
openalex   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Population Pharmacokinetic and Exposure‐Efficacy Analyses of Valbenazine in Patients with Huntington's Disease: Supporting Dose Selection for Chorea Management

The Journal of Clinical Pharmacology, EarlyView.
Abstract Valbenazine improved chorea in individuals with Huntington's disease compared to placebo in a phase 3, placebo‐controlled study (KINECT‐HD). Population pharmacokinetics (PK) and exposure–response (E–R) analyses focused on understanding the PK characteristics of valbenazine and its active metabolite, [+]‐α‐dihydrotetrabenazine ([+]‐α‐HTBZ), and
Hoa Q. Nguyen, Ryan L. Crass, Sunny Chapel, Han‐Yi Steve Kuan, Gordon Loewen, Satjit Brar   +5 more
wiley   +1 more source