Results 281 to 290 of about 191,466 (342)

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Angiotensin II and EDH Pathways Underlie the Vascular Sympatho-Modulation by 5-HT in Female Rats. [PDF]

Int J Mol Sci
Terol-Úbeda AC, Fernández-González JF, Morán A, García-Domingo M, García-Pedraza JÁ.   +4 more
europepmc   +1 more source

Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12‐week DTI study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Bipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention‐deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology ...
Kun Qin, Wen Chen, Du Lei, Ziyu Zhu, Maxwell J. Tallman, Nanfang Pan, Lisha Zhang, Luis Rodrigo Patino, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara   +10 more
wiley   +1 more source

Corticotropin‐releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress‐induced visceral sensory signals to the brain

Journal of Neuroendocrinology, EarlyView.
Corticotropin‐releasing factor (CRF) and its type 1 receptor (CRF1) are expressed in the rat colon. The vagal nodose ganglion transmits visceral information to the brain; but whether the CRF/CRF1 system is involved in vagal afferent function remains unknown.
Asuka Mano‐Otagiri, Tamotsu Shibasaki, Atsushi Sakai, Yoshihiko Kakinuma   +3 more
wiley   +1 more source

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s disease

Xiao Y, Spotorno N, An L, Bazinet V, Hansen JY, Strandberg O, Shafiei G, Behjat HH, Funck T, Salvadó G, Stomrud E, Smith R, Palmqvist S, Ossenkoppele R, Mattsson-Carlgren N, Palomero-Gallagher N, Dagher A, Misic B, Hansson O, Vogel JW.   +19 more
europepmc   +1 more source

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies. [PDF]

Int J Mol Sci
Choi G, Lee S, Yoo S, Do JT.
europepmc   +1 more source